2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid

Base Information

Chemical Name:2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid
CAS No.:98890-01-8
Molecular Formula:C₁₄H₁₃N₅O₇
Molecular Weight:363.287
Hs Code.:
DSSTox Substance ID:DTXSID30913018
Wikidata:Q82883532

Synonyms:griseolic acid B

Suppliers and Price of 2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid

Chemical Property:

Vapor Pressure:6.23E-34mmHg at 25°C
Boiling Point:889.2°Cat760mmHg
Flash Point:491.6°C
PSA：182.91000
Density:2.13g/cm³
LogP:-0.53980
XLogP3:-2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:363.08149777
Heavy Atom Count:26
Complexity:660

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OC1(CC(=O)O)C(=O)O

Technology Process of 2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid

There total 8 articles about 2-(6-aminopurin-9-yl)-5-(carboxymethyl)-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.6%

: 98889-98-6,115403-68-4
S-7'-chloro-7'-deoxygriseolic acid

: 98890-01-8
7'-deoxygriseolic acid

Guidance literature:: With zinc; In water; acetic acid;
DOI:10.1248/cpb.35.4442

Reference yield:

: 98871-19-3
(5R,6R,6aS)-5-(6-Amino-purin-9-yl)-2-((R)-benzhydryloxycarbonyl-hydroxy-methyl)-6-benzoyloxy-2,5,6,6a-tetrahydro-furo[3,2-b]furan-2-carboxylic acid benzhydryl ester

: 98890-01-8
7'-deoxygriseolic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 79.5 percent / 4-(dimethylamino)pyridine, phosphorous pentoxide / CH₂Cl₂ / 2 h / protection from moisture

2: 69.5 percent / lithium chloride / dimethylformamide / 1 h / 100 °C

3: trifluoroacetic acid, anisole / 0.5 h

4: 20 percent (v/v) ammonia / methanol / 2 h / Ambient temperature

5: 54.6 percent / zinc / acetic acid; H₂O

With dmap; phosphorus pentaoxide; ammonia; methoxybenzene; trifluoroacetic acid; lithium chloride; zinc; In methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4442

Reference yield:

: 98889-87-3
dibenzhydryl O^2'-benzoyl-O^7'-trifluoromathanesulfonylgriseolate

: 98890-01-8
7'-deoxygriseolic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 69.5 percent / lithium chloride / dimethylformamide / 1 h / 100 °C

2: trifluoroacetic acid, anisole / 0.5 h

3: 20 percent (v/v) ammonia / methanol / 2 h / Ambient temperature

4: 54.6 percent / zinc / acetic acid; H₂O

With ammonia; methoxybenzene; trifluoroacetic acid; lithium chloride; zinc; In methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4442