Technology Process of Cyclopropaneacetic acid,
a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(4-methoxyphenyl)methoxy]
methyl]-, 2-cyclopropyl-2-oxoethyl ester
There total 8 articles about Cyclopropaneacetic acid,
a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(4-methoxyphenyl)methoxy]
methyl]-, 2-cyclopropyl-2-oxoethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(tert-butoxycarbonylamino)-2-(1-((4-methoxybenzyloxy)methyl)cyclopropyl)acetic acid;
With
potassium hydroxide;
In
methanol; dichloromethane;
for 0.0333333h;
2-bromo-1-cyclopropylethan-1-one;
With
potassium iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
DOI:10.1016/j.ejmech.2016.08.024
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 6.5 h / 0 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C
2.2: 0.5 h
3.1: triethylamine / ethanol; water / 60 °C / Sonication
4.1: barium(II) hydroxide / water / Reflux
5.1: triethylamine / water; 1,4-dioxane / 20 °C
6.1: potassium hydroxide / dichloromethane; methanol / 0.03 h
6.2: 4 h / 20 °C
With
oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; potassium hydroxide; barium(II) hydroxide;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
2.1: |Swern Oxidation / 3.1: |Bucherer-Bergs Reaction;
DOI:10.1016/j.ejmech.2016.08.024
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
2.2: 6.5 h / 0 - 20 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C
3.2: 0.5 h
4.1: triethylamine / ethanol; water / 60 °C / Sonication
5.1: barium(II) hydroxide / water / Reflux
6.1: triethylamine / water; 1,4-dioxane / 20 °C
7.1: potassium hydroxide / dichloromethane; methanol / 0.03 h
7.2: 4 h / 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; potassium hydroxide; barium(II) hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
3.1: |Swern Oxidation / 4.1: |Bucherer-Bergs Reaction;
DOI:10.1016/j.ejmech.2016.08.024
