Cyclopropaneacetic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethyl)diphenyl silyl]oxy]methyl]-, 2-cyclopropyl-2-oxoethyl ester

Base Information

Chemical Name:Cyclopropaneacetic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethyl)diphenyl silyl]oxy]methyl]-, 2-cyclopropyl-2-oxoethyl ester
CAS No.:873065-95-3
Molecular Formula:C32H43NO6Si
Molecular Weight:565.782
Hs Code.:

Cyclopropaneacetic acid,
a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethyl)diphenyl
silyl]oxy]methyl]-, 2-cyclopropyl-2-oxoethyl ester

Synonyms:

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Chemical Property of Cyclopropaneacetic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethyl)diphenyl silyl]oxy]methyl]-, 2-cyclopropyl-2-oxoethyl ester

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Technology Process of Cyclopropaneacetic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethyl)diphenyl silyl]oxy]methyl]-, 2-cyclopropyl-2-oxoethyl ester

There total 9 articles about Cyclopropaneacetic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethyl)diphenyl silyl]oxy]methyl]-, 2-cyclopropyl-2-oxoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 873065-94-2
C₁₆H₂₅NO₆

: 58479-61-1
tert-butylchlorodiphenylsilane

: 873065-95-3
2-cyclopropyl-2-oxoethyl 2-(tertbutoxycarbonylamino)-2-(1-((tert-butyldiphenylsilyloxy)methyl)cyclopropyl)acetate

Guidance literature:: With 1H-imidazole; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2016.08.024

Reference yield:

: 39590-81-3
[1-(hydroxymethyl)cyclopropyl]methanol

: 873065-95-3
2-cyclopropyl-2-oxoethyl 2-(tertbutoxycarbonylamino)-2-(1-((tert-butyldiphenylsilyloxy)methyl)cyclopropyl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 6.5 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C

2.2: 0.5 h

3.1: triethylamine / ethanol; water / 60 °C / Sonication

4.1: barium(II) hydroxide / water / Reflux

5.1: triethylamine / water; 1,4-dioxane / 20 °C

6.1: potassium hydroxide / dichloromethane; methanol / 0.03 h

6.2: 4 h / 20 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water

8.1: 1H-imidazole / tetrahydrofuran

With 1H-imidazole; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Swern Oxidation / 3.1: |Bucherer-Bergs Reaction;
DOI:10.1016/j.ejmech.2016.08.024

Reference yield:

: 1559-02-0
diethyl cyclopropane-1,1-dicarboxylate

: 873065-95-3
2-cyclopropyl-2-oxoethyl 2-(tertbutoxycarbonylamino)-2-(1-((tert-butyldiphenylsilyloxy)methyl)cyclopropyl)acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 6.5 h / 0 - 20 °C / Inert atmosphere

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C

4.2: 0.5 h

5.1: triethylamine / ethanol; water / 60 °C / Sonication

6.1: barium(II) hydroxide / water / Reflux

7.1: triethylamine / water; 1,4-dioxane / 20 °C

8.1: potassium hydroxide / dichloromethane; methanol / 0.03 h

8.2: 4 h / 20 °C

9.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water

10.1: 1H-imidazole / tetrahydrofuran

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 4.1: |Swern Oxidation / 5.1: |Bucherer-Bergs Reaction;
DOI:10.1016/j.ejmech.2016.08.024