7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
• CAS No.: 5435-82-5
• Molecular Formula: C12H12N2O3
• Molecular Weight: 232.2353
• Hs Code.: 2933990090
• Mol file: 5435-82-5.mol

Synonyms:7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester;ethyl 7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate;7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-carbonsaeure-aethylester;

Chemical Property of 7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 2.17E-05mmHg at 25°C
• Boiling Point: 360.7°Cat760mmHg
• Flash Point: 172°C
• PSA: 60.67000
• Density: 1.26g/cm³
• LogP: 1.17960

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl7-methyl-4-oxopyrido[1,2-a]pyrimidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

There total 6 articles about 7-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diethyl 2-(((5-methylpyridin-2-yl)amino)methylene)malonate (19056-89-4) → ethyl 7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate (5435-82-5)

Guidance literature:

In tetrahydrofuran; at 390 ℃; under 75007.5 Torr; Temperature; Concentration;

DOI:10.1021/acs.joc.6b02520

Reference yield: 58.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate (5435-82-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 150 ℃; for 0.333333h; Microwave (CEM);

Reference yield:

diethyl 2-(((5-methylpyridin-2-yl)amino)methylene)malonate (19056-89-4) → ethyl 7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate (5435-82-5) + 7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (23443-20-1)

Guidance literature:

In tetrahydrofuran; at 325 ℃; under 75007.5 Torr; Temperature; Concentration;

DOI:10.1021/acs.joc.6b02520

upstream raw materials:

diethyl 2-(((5-methylpyridin-2-yl)amino)methylene)malonate

(5-methyl-pyridin-2-yl)amine

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

7-methyl-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylic acid

3-(5-methyl-[2]pyridylamino)-acrylic acid

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