Carbamic acid, [(1R)-3-[4-[[11-[bis(phenylmethyl)amino]undecyl]oxy]phenyl]-1-(hydroxy methyl)-1-methylpropyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1R)-3-[4-[[11-[bis(phenylmethyl)amino]undecyl]oxy]phenyl]-1-(hydroxy methyl)-1-methylpropyl]-, 1,1-dimethylethyl ester
• CAS No.: 873302-96-6
• Molecular Formula: C₄₁H₆₀N₂O₄
• Molecular Weight: 644.938
• Mol file: 873302-96-6.mol

Synonyms:

Chemical Property of Carbamic acid, [(1R)-3-[4-[[11-[bis(phenylmethyl)amino]undecyl]oxy]phenyl]-1-(hydroxy methyl)-1-methylpropyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1R)-3-[4-[[11-[bis(phenylmethyl)amino]undecyl]oxy]phenyl]-1-(hydroxy methyl)-1-methylpropyl]-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, [(1R)-3-[4-[[11-[bis(phenylmethyl)amino]undecyl]oxy]phenyl]-1-(hydroxy methyl)-1-methylpropyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(R)-1-hydroxymethyl-3-(4-hydroxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester (463952-35-4) + methanesulfonic acid 11-dibenzylaminoundecyl ester (849122-54-9) → {3-[4-(11-dibenzylamino-undecyloxy)-phenyl]-1-hydroxymethyl-1-methyl-propyl}-carbamic acid tert-butyl ester (873302-96-6)

Guidance literature:

With potassium carbonate; In ethanol; N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.bmcl.2005.09.038

Reference yield:

{3-[4-(11-dibenzylamino-undecyloxy)-phenyl]-1-hydroxymethyl-1-methyl-propyl}-carbamic acid tert-butyl ester (873302-96-6) → phosphorous acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / ammonium formate / Pd/C / methanol / Heating

2: Et₃N / tetrahydrofuran

3: aq. TFA / 20 °C

4: 1H-tetrazole / tetrahydrofuran / 20 °C

With 1H-tetrazole; ammonium formate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2005.09.038

Reference yield:

{3-[4-(11-dibenzylamino-undecyloxy)-phenyl]-1-hydroxymethyl-1-methyl-propyl}-carbamic acid tert-butyl ester (873302-96-6) → phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester (943513-74-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / ammonium formate / Pd/C / methanol / Heating

2: Et₃N / tetrahydrofuran

3: aq. TFA / 20 °C

4: 1H-tetrazole / tetrahydrofuran / 20 °C

5: aq. H₂O₂

With 1H-tetrazole; dihydrogen peroxide; ammonium formate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2005.09.038

upstream raw materials:

[(R)-1-hydroxymethyl-3-(4-hydroxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

methanesulfonic acid 11-dibenzylaminoundecyl ester

Downstream raw materials:

(R)-2-Amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butan-1-ol

[(R)-3-(4-[11-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamino)undecyloxy]phenyl)-1-hydroxymethyl-1-methylpropyl]carbamic acid tert-butyl ester

phosphoric acid 2-amino-2-methyl-4-{4-[11-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-undecyloxy]-phenyl}-butyl ester di-tert-butyl ester