1,2-Benzenediol, 4-(2,3,4,5-tetrahydro-4-methyl-1H-1,4-benzodiazepin-2-yl)-

Base Information

Chemical Name:1,2-Benzenediol, 4-(2,3,4,5-tetrahydro-4-methyl-1H-1,4-benzodiazepin-2-yl)-
CAS No.:87351-93-7
Molecular Formula:C₁₆H₁₈N₂O₂
Molecular Weight:270.331
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Benzenediol, 4-(2,3,4,5-tetrahydro-4-methyl-1H-1,4-benzodiazepin-2-yl)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,2-Benzenediol, 4-(2,3,4,5-tetrahydro-4-methyl-1H-1,4-benzodiazepin-2-yl)-

There total 7 articles about 1,2-Benzenediol, 4-(2,3,4,5-tetrahydro-4-methyl-1H-1,4-benzodiazepin-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87371-37-7
1,2,4,5-tetrahydro-2-(3,4-dimethoxyphenyl)-4-methyl-3H-1,4-benzodiazepine

: 87351-93-7
1,2,4,5-tetrahydro-2-(3,4-dihydroxyphenyl)-4-methyl-3H-1,4-benzodiazepine

Guidance literature:: With boron tribromide; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jm00367a006

Reference yield:

: 15471-89-3
α-(aminomethyl)-3,4-dimethoxybenzyl alcohol hydrochloride

: 87351-93-7
1,2,4,5-tetrahydro-2-(3,4-dihydroxyphenyl)-4-methyl-3H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / triethylamine / methanol / 0.17 h / Heating

2: 80 percent / NaBH₄ / methanol / 30 h / 0 °C

3: 100 percent / formic acid / methanol; H₂O / 0.5 h / Heating

4: 77 percent / 28percent aq. NH₃, ferrous sulfate heptahydrate / methanol / 0.5 h / Heating

5: 88 percent / conc. H₂SO₄ / trifluoroacetic acid / 0.33 h / Heating

6: 1.) BBr₃ / CH₂Cl₂ / 4 h / Ambient temperature

With ammonium hydroxide; sodium tetrahydroborate; formic acid; sulfuric acid; boron tribromide; iron(II) sulfate; triethylamine; In methanol; dichloromethane; water; trifluoroacetic acid;
DOI:10.1021/jm00367a006

Reference yield:

: 87351-92-6
α-<methyl>-3,4-dimethoxybenzyl alcohol

: 87351-93-7
1,2,4,5-tetrahydro-2-(3,4-dihydroxyphenyl)-4-methyl-3H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / conc. H₂SO₄ / trifluoroacetic acid / 0.33 h / Heating

2: 1.) BBr₃ / CH₂Cl₂ / 4 h / Ambient temperature

With sulfuric acid; boron tribromide; In dichloromethane; trifluoroacetic acid;
DOI:10.1021/jm00367a006