2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-(2,4-dichlorophenyl)-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1- oxo-, 2-propenyl ester

Base Information

Chemical Name:2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-(2,4-dichlorophenyl)-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1- oxo-, 2-propenyl ester
CAS No.:873577-68-5
Molecular Formula:C26H38Cl2N2O4Si
Molecular Weight:541.59
Hs Code.:

2,8-Diazaspiro[4.5]decane-8-carboxylic acid,
3-(2,4-dichlorophenyl)-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1-
oxo-, 2-propenyl ester

Synonyms:

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Chemical Property of 2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-(2,4-dichlorophenyl)-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1- oxo-, 2-propenyl ester

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Technology Process of 2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-(2,4-dichlorophenyl)-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1- oxo-, 2-propenyl ester

There total 8 articles about 2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-(2,4-dichlorophenyl)-2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1- oxo-, 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 873577-67-4
8-benzyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

: 2937-50-0
Allyl chloroformate

: 873577-68-5
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester

Guidance literature:: In acetonitrile; Heating;
DOI:10.1016/j.tetlet.2005.10.139

Reference yield:

: 3-allyl-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-dichloro-phenyl)-pyrrolidin-2-one

: 873577-68-5
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / LDA / tetrahydrofuran / -78 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 100 percent / polymer-bound PPh₃ / CH₂Cl₂ / -78 - 20 °C

3.1: 55 percent / NaBH(OAc)3 / 1,2-dichloro-ethane

4.1: 98 percent / acetonitrile / Heating

With sodium tris(acetoxy)borohydride; ozone; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.tetlet.2005.10.139

Reference yield:

: 873577-66-3
[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-dichloro-phenyl)-2-oxo-3-(2-oxo-ethyl)-pyrrolidin-3-yl]-acetaldehyde

: 873577-68-5
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(2,4-dichloro-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / NaBH(OAc)3 / 1,2-dichloro-ethane

2: 98 percent / acetonitrile / Heating

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.tetlet.2005.10.139