Carbamic acid, [2-[1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1,2-propadienyl]phen yl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [2-[1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1,2-propadienyl]phen yl]-, 1,1-dimethylethyl ester
• CAS No.: 873656-92-9
• Molecular Formula: C21H33NO3Si
• Molecular Weight: 375.583
• Mol file: 873656-92-9.mol

Synonyms:

Chemical Property of Carbamic acid, [2-[1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1,2-propadienyl]phen yl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [2-[1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1,2-propadienyl]phen yl]-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, [2-[1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1,2-propadienyl]phen yl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(tert-butyldimethylsiloxy)-2-(tributylstannyl)-2,3-butadiene + tert-butyl 2-iodophenylcarbamate (161117-84-6) → N-(tert-butoxycarbonyl)-2-[1-(tert-butyldimethylsiloxy)-2,3-butadien-2-yl]aniline (873656-92-9)

Guidance literature:

With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/ol052179u

Reference yield: 66.0%

N-(tert-butoxycarbonyl)-2-[1-(tert-butyldimethylsiloxy)-2,3-butadien-2-yl]aniline (873656-92-9) → 1-(tert-butoxycarbonyl)-3-hydroxymethyl-2-methylindole (914349-13-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/ol052179u

Reference yield:

N-(tert-butoxycarbonyl)-2-[1-(tert-butyldimethylsiloxy)-2,3-butadien-2-yl]aniline (873656-92-9) → N-(tert-butoxycarbonyl)-2-(1-hydroxy-2,3-butadien-2-yl)aniline (958882-75-2)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1021/ol060418n

upstream raw materials:

tert-butyl 2-iodophenylcarbamate

Downstream raw materials:

1-(tert-butoxycarbonyl)-3-hydroxymethyl-2-methylindole

N-(tert-butoxycarbonyl)-2-(1-hydroxy-2,3-butadien-2-yl)aniline

N-(tert-butoxycarbonyl)-2-(1-methanesulfonyloxy-2,3-butadien-2-yl)aniline

2-(1-acetoxy-2,3-butadien-2-yl)-N-(tert-butoxycarbonyl)aniline