2,4,5-Trimethoxyamphetamine

Base Information

• Chemical Name: 2,4,5-Trimethoxyamphetamine
• CAS No.: 1083-09-6
• Molecular Formula: C12H19 N O3
• Molecular Weight: 225.288
• UNII: 713Z3SL0TJ
• DSSTox Substance ID: DTXSID00874364
• Nikkaji Number: J13.143A
• Pharos Ligand ID: UR2NVM1ZRYM7
• ChEMBL ID: CHEMBL8389
• Mol file: 1083-09-6.mol

Synonyms:2,4,5-trimethoxyphenylisopropylamine;2,4,5-trimethoxyphenylisopropylamine hydrochloride;2,4,5-trimethoxyphenylisopropylamine hydrochloride, (+-)-isomer;2,4,5-trimethoxyphenylisopropylamine hydrochloride, (R)-isomer;2,4,5-trimethoxyphenylisopropylamine hydrochloride, (S)-isomer;2,4,5-trimethoxyphenylisopropylamine oxalate;2,4,5-trimethoxyphenylisopropylamine, (+-)-isomer;2,4,5-trimethoxyphenylisopropylamine, (R)-isomer;2,4,5-trimethoxyphenylisopropylamine, (S)-isomer;TMA-2

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2,4,5-Trimethoxyamphetamine

Chemical Property:

• Vapor Pressure: 0.000234mmHg at 25°C
• Melting Point: 130 °C
• Boiling Point: 329.5°Cat760mmHg
• PKA: 9.54±0.10(Predicted)
• Flash Point: 155°C
• PSA: 53.71000
• Density: 1.048g/cm³
• LogP: 2.30240
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 225.13649347
• Heavy Atom Count: 16
• Complexity: 201

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1OC)OC)OC)N
• Uses: TMA-2, known more formally as 2,4,5-trimethoxy-amphetamine, is a psychedelic hallucinogen which has appeared on the illicit drug market. Unlike amphetamines and cathinones, TMA-2 has no effect on monoamine re-uptake. TMA has modest effects on the 5-HT2 serotonin receptors (pEC50 values of 5.15 and 5.31 M for phosphatidylinositol release through 5-HT2A and 5HT2C, respectively). This product is intended for research and forensic applications.[Cayman Chemical]

Technology Process of 2,4,5-Trimethoxyamphetamine

There total 5 articles about 2,4,5-Trimethoxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,5-trimethoxy-β-methyl-β-nitrostyrene (134040-35-0,17231-84-4) → 2,4,5-trimethoxyamphetamine (1083-09-6,22199-15-1)

Guidance literature:

With hydrogenchloride; ethanol; acetic acid; Reduktion an Blei-Kathoden;

Reference yield:

asarone (494-40-6,2883-98-9,5273-86-9) → 2,4,5-trimethoxyamphetamine (1083-09-6,22199-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: C(NO₂)4, Py / acetone

2: LiAlH₄

With pyridine; lithium aluminium tetrahydride; tetranitromethane; In acetone;

DOI:10.1021/jm00321a058

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → 2,4,5-trimethoxyamphetamine (1083-09-6,22199-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran;

DOI:10.1021/jm00295a007

upstream raw materials:

2,4,5-trimethoxy-β-methyl-β-nitrostyrene

2.4.5-trimethoxy-1-(2-nitro-cis-propenyl)-benzene

asaraldehyde

asarone

Downstream raw materials:

(-)-3-(2,4,5-Trimethoxyphenyl)-isopropylamin

(+)-3-(2,4,5-Trimethoxyphenyl)-isopropylamin

Refernces

• 1、 Shulgin. "The six trimethoxyphenylisopropylamines (trimethoxyamphetamines).". . p. 445 - 446. Retrieved 2007/10/05.