1-(2-fluoro-3-nitrophenyl)ethanone

Base Information

• Chemical Name: 1-(2-fluoro-3-nitrophenyl)ethanone
• CAS No.: 873697-78-0
• Molecular Formula: C8H6FNO3
• Molecular Weight: 183.139
• Hs Code.: 2914700090
• Mol file: 873697-78-0.mol

Synonyms:2-Butenal,2-fluoro-3-methyl;2'-fluoro-3'-nitroacetophenone;2-fluoro-3-methyl-but-2-enal;

Chemical Property of 1-(2-fluoro-3-nitrophenyl)ethanone

Chemical Property:

• Boiling Point: 248.4±20.0 °C(Predicted)
• PSA: 62.89000
• Density: 1.336±0.06 g/cm3(Predicted)
• LogP: 2.45970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Fluoro-3-nitrophenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-fluoro-3-nitrophenyl)ethanone

There total 3 articles about 1-(2-fluoro-3-nitrophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-fluoro-3-bromonitrobenzene (58534-94-4) + tributyl(1-ethoxyvinyl)stannane (97674-02-7) → 1-(2-fluoro-3-nitro-phenyl)ethanone (873697-78-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 90 ℃; for 4h;

Reference yield:

C10H10FNO3 (943769-01-5) → 1-(2-fluoro-3-nitro-phenyl)ethanone (873697-78-0)

Guidance literature:

C₁₀H₁₀FNO₃; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

→ 1-(2-fluoro-3-nitro-phenyl)ethanone (873697-78-0)

Guidance literature:

upstream raw materials:

C₁₀H₁₀FNO₃

2-fluoro-3-bromonitrobenzene

tributyl(1-ethoxyvinyl)stannane

Downstream raw materials:

2-bromo-1-(2-fluoro-3-nitrophenyl)ethanone

3-amino-2-fluoroacetophenone