Technology Process of 1-Dodecene-6,11-diyne-4,4,9,9-tetracarboxylic acid, 12-phenyl-,
tetraethyl ester
There total 5 articles about 1-Dodecene-6,11-diyne-4,4,9,9-tetracarboxylic acid, 12-phenyl-,
tetraethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
dichloromethane;
at 20 ℃;
for 22h;
DOI:10.1021/ja054221m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1.3 g / NaOEt / tetrahydrofuran / 20 °C
2.1: NaH / tetrahydrofuran / 2 h / 20 °C
2.2: 73 percent / tetrahydrofuran / 16 h / 20 °C
3.1: NaH / tetrahydrofuran / 1 h / 20 °C
3.2: 87 percent / tetrahydrofuran / 20 °C
4.1: 71 percent / triethylamine; PdCl2(PPh3)2; CuI / CH2Cl2 / 22 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium ethanolate; sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
4.1: Sonogashiva coupling;
DOI:10.1021/ja054221m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaH / tetrahydrofuran / 1 h / 20 °C
1.2: 87 percent / tetrahydrofuran / 20 °C
2.1: 71 percent / triethylamine; PdCl2(PPh3)2; CuI / CH2Cl2 / 22 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
2.1: Sonogashiva coupling;
DOI:10.1021/ja054221m
