Triacontanamide, N-[(1S,2R,3E,5S)-2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3-heptadecenyl]-30-[[(1,1-dimeth ylethyl)diphenylsilyl]oxy]-

Base Information

• Chemical Name: Triacontanamide, N-[(1S,2R,3E,5S)-2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3-heptadecenyl]-30-[[(1,1-dimeth ylethyl)diphenylsilyl]oxy]-
• CAS No.: 873802-49-4
• Molecular Formula: C82H155NO5Si4
• Molecular Weight: 1347.48
• Mol file: 873802-49-4.mol

Synonyms:

Chemical Property of Triacontanamide, N-[(1S,2R,3E,5S)-2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3-heptadecenyl]-30-[[(1,1-dimeth ylethyl)diphenylsilyl]oxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Triacontanamide, N-[(1S,2R,3E,5S)-2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3-heptadecenyl]-30-[[(1,1-dimeth ylethyl)diphenylsilyl]oxy]-

There total 3 articles about Triacontanamide, N-[(1S,2R,3E,5S)-2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3-heptadecenyl]-30-[[(1,1-dimeth ylethyl)diphenylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

30-(tert-Butyldiphenylsilyloxy)triacontanoic acid (132910-93-1) + (2S,3R,4E,6S)-2-amino-1,3,6-tris(tert-butyldimethylsilyloxy)-4-octadecene (873802-48-3) → (2S,3R,4E,6S)-1,3,6-tris(tert-butyldimethylsilyloxy)-2-[30'-(tert-butyldiphenylsilyloxy)triacontanoylamino]-4-octadecene (873802-49-4)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1002/ejoc.200500357

Reference yield:

(2S,4E,6S)-6-hydroxy-4-sphingenine → (2S,3R,4E,6S)-1,3,6-tris(tert-butyldimethylsilyloxy)-2-[30'-(tert-butyldiphenylsilyloxy)triacontanoylamino]-4-octadecene (873802-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 350 mg / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

2: 70 percent / EDC; HOBt / CH₂Cl₂ / 12 h / 20 °C

With 2,6-dimethylpyridine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1002/ejoc.200500357

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → (2S,3R,4E,6S)-1,3,6-tris(tert-butyldimethylsilyloxy)-2-[30'-(tert-butyldiphenylsilyloxy)triacontanoylamino]-4-octadecene (873802-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 350 mg / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

2: 70 percent / EDC; HOBt / CH₂Cl₂ / 12 h / 20 °C

With 2,6-dimethylpyridine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1002/ejoc.200500357

upstream raw materials:

30-(tert-Butyldiphenylsilyloxy)triacontanoic acid

(2S,3R,4E,6S)-2-amino-1,3,6-tris(tert-butyldimethylsilyloxy)-4-octadecene

t-butyldimethylsiyl triflate