Azulene, 2-[[3-bromo-4-(methoxymethoxy)phenyl]methyl]-

Base Information

• Chemical Name: Azulene, 2-[[3-bromo-4-(methoxymethoxy)phenyl]methyl]-
• CAS No.: 873804-37-6
• Molecular Formula: C19H17BrO2
• Molecular Weight: 357.247
• Mol file: 873804-37-6.mol

Synonyms:

Chemical Property of Azulene, 2-[[3-bromo-4-(methoxymethoxy)phenyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Azulene, 2-[[3-bromo-4-(methoxymethoxy)phenyl]methyl]-

There total 1 articles about Azulene, 2-[[3-bromo-4-(methoxymethoxy)phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

1-[3-bromo-4-(methoxymethoxy)phenyl]acetone (873804-36-5) + cyclohepta[b]furan-2(2H)-one (4481-35-0) → 2-[3-bromo-4-(methoxymethoxy)benzyl]azulene (873804-37-6)

Guidance literature:

1-[3-bromo-4-(methoxymethoxy)phenyl]acetone; With pyrrolidine; In toluene;

cyclohepta[b]furan-2(2H)-one; In isopropyl alcohol; for 19h; Heating / reflux;

Reference yield: 50.0%

2-[3-bromo-4-(methoxymethoxy)benzyl]azulene (873804-37-6) + (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one (32469-28-6,55515-28-1,55515-29-2,32384-65-9) → sodium 4-(azulen-2-ylmethyl)-2-(1-methoxy-D-glucopyranosyl)phenolate

Guidance literature:

2-[3-bromo-4-(methoxymethoxy)benzyl]azulene; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -75 - -70 ℃; for 0.5h;

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; toluene; at -75 - -60 ℃; for 19h;

With hydrogenchloride; sodium hydroxide; water; more than 3 stages;

upstream raw materials:

1-[3-bromo-4-(methoxymethoxy)phenyl]acetone

cyclohepta[b]furan-2(2H)-one

Refernces