2,5-DIHYDROXYBENZOHYDRAZIDE

Base Information

• Chemical Name: 2,5-DIHYDROXYBENZOHYDRAZIDE
• CAS No.: 15791-90-9
• Molecular Formula: C7H8 N2 O3
• Molecular Weight: 168.152
• Hs Code.: 2928000090
• Mol file: 15791-90-9.mol

Synonyms:Gentisic acid, hydrazide(6CI,7CI,8CI); (2,5-Dihydroxybenzoyl)hydrazine; 2,5-Dihydroxybenzohydrazide;2,5-Dihydroxybenzoic acid hydrazide;5-Hydroxysalicylic acid hydrazide; NSC 409919

Chemical Property of 2,5-DIHYDROXYBENZOHYDRAZIDE

Chemical Property:

• Melting Point: 209-210 °C
• PKA: 9.15±0.43(Predicted)
• PSA: 95.58000
• Density: 1.477g/cm³
• LogP: 0.79250

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dihydroxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DIHYDROXYBENZOHYDRAZIDE

There total 4 articles about 2,5-DIHYDROXYBENZOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,5-dihydroxybenzoate (3943-91-7) → 2,5-dihydroxybenzohydrazide (15791-90-9)

Guidance literature:

With hydrazine hydrate;

DOI:10.1021/jo50012a013

Reference yield:

Methyl 2,5-dihydroxybenzoate (2150-46-1) → 2,5-dihydroxybenzohydrazide (15791-90-9)

Guidance literature:

With hydrazine hydrate;

DOI:10.1021/jo50012a013

Reference yield:

2,5-dihydroxybenzoic acid. (490-79-9) → 2,5-dihydroxybenzohydrazide (15791-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / neat (no solvent) / 120 °C / Sealed tube

With sulfuric acid; hydrazine hydrate; In neat (no solvent);

DOI:10.1002/cmdc.201700186

upstream raw materials:

Methyl 2,5-dihydroxybenzoate

ethyl 2,5-dihydroxybenzoate

2,5-dihydroxybenzoic acid.