7-Oxa-2,6,11,15-tetraazahexadecanedioic acid, 6-[(2-nitrophenyl)sulfonyl]-11-[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) 16-(phenylmethyl) ester

Base Information

• Chemical Name: 7-Oxa-2,6,11,15-tetraazahexadecanedioic acid, 6-[(2-nitrophenyl)sulfonyl]-11-[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) 16-(phenylmethyl) ester
• CAS No.: 873933-22-3
• Molecular Formula: C₃₆H₄₇N₅O₁₁S
• Molecular Weight: 757.862
• Mol file: 873933-22-3.mol

Synonyms:

Chemical Property of 7-Oxa-2,6,11,15-tetraazahexadecanedioic acid, 6-[(2-nitrophenyl)sulfonyl]-11-[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) 16-(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Oxa-2,6,11,15-tetraazahexadecanedioic acid, 6-[(2-nitrophenyl)sulfonyl]-11-[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) 16-(phenylmethyl) ester

There total 5 articles about 7-Oxa-2,6,11,15-tetraazahexadecanedioic acid, 6-[(2-nitrophenyl)sulfonyl]-11-[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) 16-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(N-2-nitrobenzenesulfonyl)aminooxy-4-(N-benzyloxycarbonyl)aza-1-(N-benzyloxycarbonyl)aminoheptane (873933-21-2) + tert-butyl (3-iodopropyl)carbamate (167479-01-8) → 1-(N-tert-butyloxycarbonyl)amino-4-(N-2-nitrobenzenesulfonyl)aza-5-oxa-9-(N-benzyloxycarbonyl)aza-12-(N-benzyloxycarbonyl)aminododecane (873933-22-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1007/s11171-005-0026-4

Reference yield:

7-(1'-ethoxyethylidene)aminooxy-4-(N-benzyloxycarbonyl)aza-1-(N-benzyloxycarbonyl)aminoheptane → 1-(N-tert-butyloxycarbonyl)amino-4-(N-2-nitrobenzenesulfonyl)aza-5-oxa-9-(N-benzyloxycarbonyl)aza-12-(N-benzyloxycarbonyl)aminododecane (873933-22-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / HCl / propan-2-ol / 0.17 h / 20 °C

2: 65 percent / CH₂Cl₂ / 24 h / 20 °C

3: K₂CO₃ / dimethylformamide / 24 h / 20 °C

With hydrogenchloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1007/s11171-005-0026-4

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-(N-tert-butyloxycarbonyl)amino-4-(N-2-nitrobenzenesulfonyl)aza-5-oxa-9-(N-benzyloxycarbonyl)aza-12-(N-benzyloxycarbonyl)aminododecane (873933-22-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / H₂O; dioxane / 16 h / 20 °C

2: NaI / acetone / 18 h / 20 °C

3: K₂CO₃ / dimethylformamide / 24 h / 20 °C

With sodium hydroxide; potassium carbonate; sodium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1007/s11171-005-0026-4

upstream raw materials:

7-(N-2-nitrobenzenesulfonyl)aminooxy-4-(N-benzyloxycarbonyl)aza-1-(N-benzyloxycarbonyl)aminoheptane

tert-butyl (3-iodopropyl)carbamate

di-tert-butyl dicarbonate

3-bromopropylamine tert-butylcarbamate