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Antibiotic K 252a

Base Information
  • Chemical Name:Antibiotic K 252a
  • CAS No.:97161-97-2
  • Deprecated CAS:105450-17-7,108645-76-7,151004-74-9
  • Molecular Formula:C27H21N3O5
  • Molecular Weight:467.481
  • Hs Code.:29349990
  • European Community (EC) Number:640-127-4
  • UNII:IV7H45AM5B
  • DSSTox Substance ID:DTXSID40880065
  • Wikipedia:K252a
  • Wikidata:Q5931064
  • NCI Thesaurus Code:C1382
  • Pharos Ligand ID:KBZD8QKCM3MX
  • Metabolomics Workbench ID:98407
  • ChEMBL ID:CHEMBL281948
  • Mol file:97161-97-2.mol
Antibiotic K 252a

Synonyms:3'-(S)-epi-K-252a;K 252;K 252a;K 252b;K 252c;K 252d;K-252;K-252a;K-252b;K-252d;K252a;staurosporine aglycone;staurosporinone

Suppliers and Price of Antibiotic K 252a
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • K252a
  • 1mg
  • $ 250.00
  • Usbiological
  • K252a
  • 1mg
  • $ 699.00
  • Usbiological
  • K 252a
  • 200ug
  • $ 593.00
  • Usbiological
  • K252a
  • 100ug
  • $ 425.00
  • Usbiological
  • K252a
  • 500ug
  • $ 382.00
  • Usbiological
  • K-252a
  • 100ug
  • $ 299.00
  • Tocris
  • K252a ≥98%(HPLC)
  • 200U
  • $ 292.00
  • Sigma-Aldrich
  • InSolution K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem
  • 100ug
  • $ 193.00
  • Sigma-Aldrich
  • K-252a from Nonomuraea longicatena, ≥98% (HPLC)
  • 100 μg
  • $ 188.00
  • Sigma-Aldrich
  • K-252a Ready Made Solution, from Nonomuraea longicatena, >98%
  • 200 μL
  • $ 186.00
Total 8 raw suppliers
Chemical Property of Antibiotic K 252a
Chemical Property:
  • Vapor Pressure:1.02E-19mmHg at 25°C 
  • Melting Point:960.5oC 
  • Boiling Point:685.3°Cat760mmHg 
  • Flash Point:368.2°C 
  • PSA:94.72000 
  • Density:1.67g/cm3 
  • LogP:3.98390 
  • Storage Temp.:−20°C 
  • Solubility.:DMF: 1 mg/mL 
  • XLogP3:2.8
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:2
  • Exact Mass:467.14812078
  • Heavy Atom Count:35
  • Complexity:977
Purity/Quality:

98% *data from raw suppliers

K252a *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22-24/25 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
  • Isomeric SMILES:C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
  • Recent ClinicalTrials:Hepatotoxicity Related to Protein Kinase Inhibitors
  • Uses Protein kinase inhibitor
Technology Process of Antibiotic K 252a

There total 47 articles about Antibiotic K 252a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 6h;
DOI:10.1021/ja9713035

Reference yield: 83.0%

Guidance literature:
With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; for 6h;
DOI:10.1021/ja00146a039

Reference yield: 83.0%

Guidance literature:
With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 6h;
DOI:10.1021/ja9713035
upstream raw materials:

C36H31N3O7

dimethyl sulfate

K-252b

diazomethane

Downstream raw materials:

K-252b

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