5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

• Chemical Name: 5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione
• CAS No.: 68160-48-5
• Molecular Formula: C₈H₁₁BrN₂O₃
• Molecular Weight: 263.091
• Mol file: 68160-48-5.mol

Synonyms:Barbituric acid, 5-(2-bromoethyl)-5-ethyl- (5CI);5-(2-Bromoethyl)-5-ethylbarbituric acid; NSC 46902

Chemical Property of 5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.505g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione

There total 2 articles about 5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

5-ethyl-5-(2-hydroxy-ethyl)-barbituric acid (710-77-0) → 5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6-trione (68160-48-5)

Guidance literature:

With phosphorus tribromide; for 1h; Heating;

Reference yield:

ethyl-(2-hydroxy-ethyl)-malonic acid diethyl ester → 5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6-trione (68160-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 62.9 percent / NaOEt

2: 52 percent / PBr₃ / 1 h / Heating

With sodium ethanolate; phosphorus tribromide;

Reference yield:

5-(2-bromoethyl)-5-ethylpyrimidine-2,4,6-trione (68160-48-5) → N,N-bis-[2-(5-ethyl-2,4,6-trioxo-hexahydro-pyrimidin-5-yl)-ethyl]-glycin-anilide

Guidance literature:

DOI:10.1021/ja01119a038

upstream raw materials:

5-ethyl-5-(2-hydroxy-ethyl)-barbituric acid