3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE
• CAS No.: 3832-24-4
• Molecular Formula: C3H6F3NO
• Molecular Weight: 165.543
• Hs Code.: 2922199090
• Mol file: 3832-24-4.mol

Synonyms:2-propanol, 3-amino-1,1,1-trifluoro-;Aminotrifluoropropanol;

Chemical Property of 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.0308mmHg at 25°C
• Melting Point: 99oC
• Boiling Point: 176.5 °C at 760 mmHg
• Flash Point: 60.5 °C
• PSA: 46.25000
• Density: 1.344 g/cm³
• LogP: 1.37060

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-1,1,1-trifluoropropan-2-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE

There total 2 articles about 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3,3,3-trifluoro-2-hydroxypropyl)benzamide → 3-amino-1,1,1-trifluoropropan-2-ol hydrochloride (1 :1) (3832-24-4)

Guidance literature:

With hydrogenchloride; In ethanol; water;

Reference yield:

C16H14F3NO → 3-amino-1,1,1-trifluoropropan-2-ol hydrochloride (1 :1) (3832-24-4)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 60 ℃; for 0.5h; pH=< 4;

DOI:10.1021/acs.oprd.8b00133

Reference yield: 70.0%

3-chloro-2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoic acid + 3-amino-1,1,1-trifluoropropan-2-ol hydrochloride (1 :1) (3832-24-4) → 3-chloro-2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]-N-[3,3,3-trifluoro-2-hydroxypropyl]benzamide

Guidance literature:

3-chloro-2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

3-amino-1,1,1-trifluoropropan-2-ol hydrochloride (1 :1); With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Refernces

• 1、 -. "Peptidase inhibitors". . . Retrieved 2008/06/13.