2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

Base Information

Chemical Name:2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine
CAS No.:874143-26-7
Molecular Formula:C13H14ClN3O3
Molecular Weight:295.725
Hs Code.:
DSSTox Substance ID:DTXSID001230391

Synonyms:2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine;SCHEMBL1122069;WLISXOGSZMQLHI-UHFFFAOYSA-N;DTXSID001230391;AKOS009154454;874143-26-7;2-chloro-6-(3,4,5-trimethoxyphenylamino)-pyrazine;6-Chloro-N-(3,4,5-trimethoxyphenyl)-2-pyrazinamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:295.0723690
Heavy Atom Count:20
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)Cl

Technology Process of 2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

There total 2 articles about 2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 874143-26-7
N-(3,4,5-trimethoxyphenyl)-6-chloro-2-pyrazinamine

Guidance literature:: With nickel(II) bromide trihydrate; N,N-dimethyl-cyclohexanamine; C₇₀H₇₅BN₂; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 50 ℃; for 12h; Inert atmosphere; Irradiation;

Reference yield: 61.1%

: 4774-14-5
2,6-dichloropyrazine

: 24313-88-0
3,4,5-Trimethoxyaniline

: 874143-26-7
N-(3,4,5-trimethoxyphenyl)-6-chloro-2-pyrazinamine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; for 4h; Heating;
DOI:10.1021/jm050983g

Reference yield: 71.0%

: 874143-26-7
N-(3,4,5-trimethoxyphenyl)-6-chloro-2-pyrazinamine

: 108-95-2,27073-41-2
phenol

: 894417-96-0
2-(3,4,5-trimethoxyphenylamino)-6-(phenyloxy)-pyrazine

Guidance literature:: phenol; With potassium tert-butylate; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

N-(3,4,5-trimethoxyphenyl)-6-chloro-2-pyrazinamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm070776b