(2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
CAS No.:874163-00-5
Molecular Formula:C18H24N2O6
Molecular Weight:338.39900
Hs Code.:
DSSTox Substance ID:DTXSID201119505

Synonyms:(2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S,4R)-4-(((BENZYLOXY)CARBONYL)AMINO)-1-(TERT-BUTOXYCARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID;SCHEMBL1374899;KFRRDHBQRJQRRO-KGLIPLIRSA-N;DTXSID201119505;W12062;EN300-24441526;(2S,4R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonylamino)pyrrolidine-2-carboxylic acid;(2S,4R)-4-{[(benzyloxy)carbonyl]amino}-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid;1-(1,1-Dimethylethyl) (2S,4R)-4-[[(phenylmethoxy)carbonyl]amino]-1,2-pyrrolidinedicarboxylate

Suppliers and Price of (2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Tert-Butyl(2-(((benzyloxy)carbonyl)amino)ethyl)(2-hydroxyethyl)carbamate
5g
$ 1072.00

Acrotein
(4R)-1-Boc-4-(Cbz-amino)-L-proline 97%
1g
$ 513.33

Acrotein
(4R)-1-Boc-4-(Cbz-amino)-L-proline 97%
0.5g
$ 330.00

Acrotein
(4R)-1-Boc-4-(Cbz-amino)-L-proline 97%
0.25g
$ 220.00

Total 7 raw suppliers

Chemical Property of (2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Chemical Property:

PSA：88.10000
LogP:2.53310
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:364.16343649
Heavy Atom Count:26
Complexity:524

Purity/Quality:

99% ^*data from raw suppliers

Tert-Butyl(2-(((benzyloxy)carbonyl)amino)ethyl)(2-hydroxyethyl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)O)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of (2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

There total 6 articles about (2S,4R)-4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: N-Boc-tAmp(Cbz)-OMe

: 874163-00-5
(2S,4R)-1-(tert-butoxycarbonyl)-4-(N-benzyloxycarbonyl)aminoproline

Guidance literature:: N-Boc-tAmp(Cbz)-OMe; With sodium hydroxide; In methanol; at 0 - 20 ℃;

With citric acid; In water;
DOI:10.1016/j.bmc.2008.11.010

Reference yield: 63.0%

: 132622-69-6
(2S,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 874163-00-5
(2S,4R)-1-(tert-butoxycarbonyl)-4-(N-benzyloxycarbonyl)aminoproline

Guidance literature:: With sodium hydroxide; at 0 - 20 ℃;
DOI:10.1021/jm050644n

Reference yield:

: 1217446-43-9
(2S,4R)-4-aminopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 874163-00-5
(2S,4R)-1-(tert-butoxycarbonyl)-4-(N-benzyloxycarbonyl)aminoproline

Guidance literature:: (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester hydrochloride; benzyl chloroformate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With potassium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water;