[(2-hydroxynaphthalen-1-yl)methylidene]propanedinitrile

Base Information

• Chemical Name: [(2-hydroxynaphthalen-1-yl)methylidene]propanedinitrile
• CAS No.: 101756-32-5
• Molecular Formula: C14H8 N2 O
• Molecular Weight: 220.2261
• Mol file: 101756-32-5.mol

Synonyms:Propanedinitrile,[(2-hydroxy-1-naphthalenyl)methylene]- (9CI); NSC 663984

Chemical Property of [(2-hydroxynaphthalen-1-yl)methylidene]propanedinitrile

Chemical Property:

• Vapor Pressure: 6.03E-09mmHg at 25°C
• Boiling Point: 456.3°Cat760mmHg
• Flash Point: 229.8°C
• Density: 1.326g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(2-hydroxynaphthalen-1-yl)methylidene]propanedinitrile

There total 2 articles about [(2-hydroxynaphthalen-1-yl)methylidene]propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxynaphthalene-1-carbaldehyde (708-06-5) + malononitrile (109-77-3) → 2-cyano-3-(2-hydroxynaphth-1-yl)acrylonitrile (101756-32-5)

Guidance literature:

With piperidine; In ethanol; for 0.5h; Heating;

Reference yield:

→ 2-cyano-3-(2-hydroxynaphth-1-yl)acrylonitrile (101756-32-5)

Guidance literature:

Reference yield: 85.0%

N-(4-sulfamoylphenyl)malonamic acid ethyl ester (10265-44-8) + 2-cyano-3-(2-hydroxynaphth-1-yl)acrylonitrile (101756-32-5) → 2-amino-3-[N(4-aminosulfonyl)phenyl]-12c-hydro-4-hydroxypyrido[3,4-c]benzo[f]coumarin-1-carbonitrile

Guidance literature:

With piperidine; In butan-1-ol; for 2.5h; Heating;

DOI:10.1080/10426509808035678

upstream raw materials:

2-hydroxynaphthalene-1-carbaldehyde

malononitrile

Downstream raw materials:

4-[2-amino-3-cyano-4-(2-hydroxy-1-naphthyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl]benzenesulfonamide

2-amino-7,7-dimethyl-4-(2-hydroxy-1-naphthyl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-amino-4-(2-hydroxynaphthalen-1-yl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

4-[2-amino-3-cyano-4-(2-hydroxynaphthalen-1-yl)-5-oxo-4H-indeno[1,2-b]-pyridin-1-(5H)-yl]benzenesulfonamide

Refernces

• 1、 Buzzetti,Brasca,Crugnola,Fustinoni,Longo,Penco,Dalla Zonca,Comoglio. "cinnamamide analogs as inhibitors of protein tyrosine kinases". . p. 615 - 636. Retrieved 2007/10/02.