Technology Process of N-[[(1S)-11-Bromo-1,2,7,8,13,13bβ-hexahydro-10-hydroxy[1,6,2]oxathiazepino[2',3':1,2]pyrido[3,4-b]indol]-1α-yl]-2-hydroxyacetamide
There total 14 articles about N-[[(1S)-11-Bromo-1,2,7,8,13,13bβ-hexahydro-10-hydroxy[1,6,2]oxathiazepino[2',3':1,2]pyrido[3,4-b]indol]-1α-yl]-2-hydroxyacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: CH2Cl2 / Ambient temperature
2: 96 percent / TFA / CH2Cl2 / 2 h / -78 °C
3: mCPBA
4: 22 percent / TsOH / CH2Cl2 / 2 h / Ambient temperature
5: 33 percent / BBr3
With
boron tribromide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: iPr2NEt / CH2Cl2 / 1 h / Ambient temperature
2: DIBAL / toluene / 2 h / -78 °C
3: CH2Cl2 / Ambient temperature
4: 96 percent / TFA / CH2Cl2 / 2 h / -78 °C
5: mCPBA
6: 22 percent / TsOH / CH2Cl2 / 2 h / Ambient temperature
7: 33 percent / BBr3
With
boron tribromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
dichloromethane; toluene;
