1H-Azepine-1-carboxylic acid, 3-[[[4-[acetyl[(1,1-dimethylethoxy)carbonyl]amino]phenyl]sulfonyl](2-meth ylpropyl)amino]hexahydro-2-oxo-, 1,1-dimethylethyl ester, (3S)-

Base Information

Chemical Name:1H-Azepine-1-carboxylic acid, 3-[[[4-[acetyl[(1,1-dimethylethoxy)carbonyl]amino]phenyl]sulfonyl](2-meth ylpropyl)amino]hexahydro-2-oxo-, 1,1-dimethylethyl ester, (3S)-
CAS No.:874339-75-0
Molecular Formula:C28H43N3O8S
Molecular Weight:581.731
Hs Code.:

1H-Azepine-1-carboxylic acid,
3-[[[4-[acetyl[(1,1-dimethylethoxy)carbonyl]amino]phenyl]sulfonyl](2-meth
ylpropyl)amino]hexahydro-2-oxo-, 1,1-dimethylethyl ester, (3S)-

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Chemical Property of 1H-Azepine-1-carboxylic acid, 3-[[[4-[acetyl[(1,1-dimethylethoxy)carbonyl]amino]phenyl]sulfonyl](2-meth ylpropyl)amino]hexahydro-2-oxo-, 1,1-dimethylethyl ester, (3S)-

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Technology Process of 1H-Azepine-1-carboxylic acid, 3-[[[4-[acetyl[(1,1-dimethylethoxy)carbonyl]amino]phenyl]sulfonyl](2-meth ylpropyl)amino]hexahydro-2-oxo-, 1,1-dimethylethyl ester, (3S)-

There total 4 articles about 1H-Azepine-1-carboxylic acid, 3-[[[4-[acetyl[(1,1-dimethylethoxy)carbonyl]amino]phenyl]sulfonyl](2-meth ylpropyl)amino]hexahydro-2-oxo-, 1,1-dimethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 874339-75-0
(3S)-3-{[4-(acetyl-tert-butoxycarbonyl-amino)-benzenesulfonyl]-isobutyl-amino}-2-oxo-azepane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / STAB / CH₂Cl₂

2: 88 percent / TEA / ethyl acetate

3: DMAP / acetonitrile

With dmap; TEA; sodium tris(acetoxy)borohydride; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2006.04.011

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 449806-97-7
Nα-isobutyl-Nα-(4-acetamidobenzenesulfonyl)-L-α-amino-ε-caprolactam

: 874339-75-0
(3S)-3-{[4-(acetyl-tert-butoxycarbonyl-amino)-benzenesulfonyl]-isobutyl-amino}-2-oxo-azepane-1-carboxylic acid tert-butyl ester

Guidance literature:: With dmap; In acetonitrile;
DOI:10.1016/j.bmcl.2006.04.011

Reference yield:

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 874339-75-0
(3S)-3-{[4-(acetyl-tert-butoxycarbonyl-amino)-benzenesulfonyl]-isobutyl-amino}-2-oxo-azepane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / TEA / ethyl acetate

2: DMAP / acetonitrile

With dmap; TEA; In ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2006.04.011