Pyrrolo[1,2-c]pyrimidine-2,4(1H)-dicarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-3,5,6,7-tetrahydro-3-[9-[(4-meth oxyphenyl)methoxy]nonyl]-, 2-(1,1-dimethylethyl) ester, (3R)-

Base Information

Chemical Name:Pyrrolo[1,2-c]pyrimidine-2,4(1H)-dicarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-3,5,6,7-tetrahydro-3-[9-[(4-meth oxyphenyl)methoxy]nonyl]-, 2-(1,1-dimethylethyl) ester, (3R)-
CAS No.:874349-39-0
Molecular Formula:C35H53N3O8
Molecular Weight:643.821
Hs Code.:

Pyrrolo[1,2-c]pyrimidine-2,4(1H)-dicarboxylic acid,
1-[[(1,1-dimethylethoxy)carbonyl]imino]-3,5,6,7-tetrahydro-3-[9-[(4-meth
oxyphenyl)methoxy]nonyl]-, 2-(1,1-dimethylethyl) ester, (3R)-

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Chemical Property of Pyrrolo[1,2-c]pyrimidine-2,4(1H)-dicarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-3,5,6,7-tetrahydro-3-[9-[(4-meth oxyphenyl)methoxy]nonyl]-, 2-(1,1-dimethylethyl) ester, (3R)-

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Technology Process of Pyrrolo[1,2-c]pyrimidine-2,4(1H)-dicarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-3,5,6,7-tetrahydro-3-[9-[(4-meth oxyphenyl)methoxy]nonyl]-, 2-(1,1-dimethylethyl) ester, (3R)-

There total 13 articles about Pyrrolo[1,2-c]pyrimidine-2,4(1H)-dicarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-3,5,6,7-tetrahydro-3-[9-[(4-meth oxyphenyl)methoxy]nonyl]-, 2-(1,1-dimethylethyl) ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691006-73-2
(2S,3S,3aR,4S)-3-Hydroxymethyl-2-[9-(4-methoxy-benzyloxy)-nonyl]-hexahydro-pyrrolo[1,2-b]isoxazol-4-ol

: 874349-39-0
1-tert-butoxycarbonylimino-3-[9-(4-methoxy-benzyloxy)-nonyl]-3,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-2,4-dicarboxylic acid 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 81 percent / pyridine / 19 h / 20 °C

2: 58 percent / DMAP; pyridine / 20 h / 20 °C

3: 94 percent / n-Bu₃SnH; AIBN / toluene / 0.5 h / 110 °C

4: H₂ / Pd(OH)2/C / ethanol / 3 h / 20 °C

5: 830 mg / HgCl₂; Et₃N / dimethylformamide / 0.5 h / 20 °C

6: 100 percent / DEAD; PPh₃ / toluene / 0.5 h / 20 °C

7: 580 mg / TBAF / tetrahydrofuran / 2 h / 20 °C

8: 47 percent / tetra-n-propylammonium perruthenate; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

9: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 14 h / 20 °C

With pyridine; dmap; sodium chlorite; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; triethylamine; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 6: Mitsunobu reaction;
DOI:10.1002/chem.200500852

Reference yield:

: 691006-74-3
3-(tert-butyl-dimethyl-silanyloxymethyl)-2-[9-(4-methoxy-benzyloxy)-nonyl]-hexahydro-pyrrolo[1,2-b]isoxazole

: 874349-39-0
1-tert-butoxycarbonylimino-3-[9-(4-methoxy-benzyloxy)-nonyl]-3,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-2,4-dicarboxylic acid 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd(OH)2/C / ethanol / 3 h / 20 °C

2: 830 mg / HgCl₂; Et₃N / dimethylformamide / 0.5 h / 20 °C

3: 100 percent / DEAD; PPh₃ / toluene / 0.5 h / 20 °C

4: 580 mg / TBAF / tetrahydrofuran / 2 h / 20 °C

5: 47 percent / tetra-n-propylammonium perruthenate; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

6: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 14 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 3: Mitsunobu reaction;
DOI:10.1002/chem.200500852

Reference yield:

: 874349-36-7
(2S,3S)-1-(tert-Butyl-dimethyl-silanyloxy)-12-(4-methoxy-benzyloxy)-2-(S)-pyrrolidin-2-yl-dodecan-3-ol

: 874349-39-0
1-tert-butoxycarbonylimino-3-[9-(4-methoxy-benzyloxy)-nonyl]-3,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-2,4-dicarboxylic acid 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 830 mg / HgCl₂; Et₃N / dimethylformamide / 0.5 h / 20 °C

2: 100 percent / DEAD; PPh₃ / toluene / 0.5 h / 20 °C

3: 580 mg / TBAF / tetrahydrofuran / 2 h / 20 °C

4: 47 percent / tetra-n-propylammonium perruthenate; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

5: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 14 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 2: Mitsunobu reaction;
DOI:10.1002/chem.200500852