1-(6-Ethynyl-pyridin-2-yl)-ethanone

Base Information

Chemical Name:1-(6-Ethynyl-pyridin-2-yl)-ethanone
CAS No.:874379-35-8
Molecular Formula:C6H7NO
Molecular Weight:145.161
Hs Code.:
DSSTox Substance ID:DTXSID90470910
Wikidata:Q82299116
Mol file:874379-35-8.mol

Synonyms:1-(6-ethynylpyridin-2-yl)ethanone;874379-35-8;1-(6-Ethynyl-pyridin-2-yl)-ethanone;1-(6-ethynylpyridin-2-yl)ethan-1-one;SCHEMBL17963045;DTXSID90470910;AKOS006239777;Ethanone, 1-(6-ethynyl-2-pyridinyl)-;CS-0415912;F83984;EN300-4271452

Suppliers and Price of 1-(6-Ethynyl-pyridin-2-yl)-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE 95.00%
2G
$ 1674.75

AccelPharmtech
1-(6-ethynyl-2-pyridinyl)-Ethanone 97.00%
25G
$ 6000.00

AccelPharmtech
1-(6-ethynyl-2-pyridinyl)-Ethanone 97.00%
1G
$ 1890.00

Total 15 raw suppliers

Chemical Property of 1-(6-Ethynyl-pyridin-2-yl)-ethanone

Chemical Property:

Boiling Point:261.3 °C at 760 mmHg
Flash Point:118.7 °C
PSA：29.96000
LogP:1.26550
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:145.052763847
Heavy Atom Count:11
Complexity:201

Purity/Quality:

99% ^*data from raw suppliers

1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC=CC(=N1)C#C

Technology Process of 1-(6-Ethynyl-pyridin-2-yl)-ethanone

There total 4 articles about 1-(6-Ethynyl-pyridin-2-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.32%

: 874379-34-7
1-(6-((trimethylsilyl)ethynyl)pyridin-2-yl)ethan-1-one

: 874379-35-8
1-(6-ethynylpyridin-2-yl)ethan-1-one

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 0.75h;

Reference yield: 50.0%

: 874379-36-9
2-acetyl-6-(3-methylbutyn-1-yl)pyridine

: 874379-35-8
1-(6-ethynylpyridin-2-yl)ethan-1-one

Guidance literature:: With sodium hydroxide; In ethanol; at 50 ℃; for 4h;
DOI:10.1021/jo051937r

Reference yield:

: 49669-13-8
1-(6-bromopyridin-2-yl)-ethanone

: 874379-35-8
1-(6-ethynylpyridin-2-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / CuI; i-Pr₂NH / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / Heating

2: 50 percent / NaOH / ethanol / 4 h / 50 °C

With sodium hydroxide; copper(l) iodide; diisopropylamine; bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran; ethanol;
DOI:10.1021/jo051937r