Technology Process of 2H-Azepin-2-one,
6-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-6-phenyl-,
(6S)-
There total 10 articles about 2H-Azepin-2-one,
6-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-6-phenyl-,
(6S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-3-phenylcyclohexanone;
With
sodium azide; trifluoroacetic acid;
In
water; benzene;
at 65 ℃;
for 1h;
In
ethanol; n-heptane;
Resolution of racemate;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 1 h / 0 - 20 °C
1.2: 20 °C
2.1: trimethylamine hydrochloride / water; N,N-dimethyl-formamide / 6 h / 93 °C
3.1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark
4.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C
5.1: sodium tetrahydroborate / methanol / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C
7.1: hydrogenchloride / water; acetone / 2 h / Reflux
8.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C
8.2: Chiralpak AS semi-prep column / Resolution of racemate
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; pyridinium p-toluenesulfonate; trimethylamine hydrochloride; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene;
2.1: |Michael Addition / 8.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trimethylamine hydrochloride / water; N,N-dimethyl-formamide / 6 h / 93 °C
2.1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark
3.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C
4.1: sodium tetrahydroborate / methanol / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C
6.1: hydrogenchloride / water; acetone / 2 h / Reflux
7.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C
7.2: Chiralpak AS semi-prep column / Resolution of racemate
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; pyridinium p-toluenesulfonate; trimethylamine hydrochloride; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid;
In
methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene;
1.1: |Michael Addition / 7.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010
