1H-Azepine, 4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-4-phenyl-, (4R)-

Base Information

Chemical Name:1H-Azepine, 4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-4-phenyl-, (4R)-
CAS No.:874454-08-7
Molecular Formula:C22H23F6NO
Molecular Weight:431.421
Hs Code.:

Synonyms:

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Chemical Property of 1H-Azepine, 4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-4-phenyl-, (4R)-

Chemical Property:

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Technology Process of 1H-Azepine, 4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-4-phenyl-, (4R)-

There total 10 articles about 1H-Azepine, 4-[[[3,5-bis(trifluoromethyl)phenyl]methoxy]methyl]hexahydro-4-phenyl-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 874453-48-2
4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepan-2-one

: 874454-08-7
(R)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Guidance literature:: With borane-THF; In diethyl ether; at 20 - 65 ℃; for 1h;

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 874454-08-7
(R)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 20 °C

2.1: trimethylamine hydrochloride / water; N,N-dimethyl-formamide / 6 h / 93 °C

3.1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark

4.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C

5.1: sodium tetrahydroborate / methanol / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

7.1: hydrogenchloride / water; acetone / 2 h / Reflux

8.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C

8.2: Chiralpak AS semi-prep column / Resolution of racemate

9.1: borane-THF / 20 - 65 °C

9.2: 2 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; sodium azide; borane-THF; pyridinium p-toluenesulfonate; trimethylamine hydrochloride; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene; 2.1: |Michael Addition / 8.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010

Reference yield:

: 10345-87-6
3-phenylcyclohex-2-enone

: 874454-08-7
(R)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Guidance literature:: Multi-step reaction with 8 steps

1.1: trimethylamine hydrochloride / water; N,N-dimethyl-formamide / 6 h / 93 °C

2.1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark

3.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C

4.1: sodium tetrahydroborate / methanol / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

6.1: hydrogenchloride / water; acetone / 2 h / Reflux

7.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C

7.2: Chiralpak AS semi-prep column / Resolution of racemate

8.1: borane-THF / 20 - 65 °C

8.2: 2 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; sodium azide; borane-THF; pyridinium p-toluenesulfonate; trimethylamine hydrochloride; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; In methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene; 1.1: |Michael Addition / 7.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010