1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5- yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-

Base Information

Chemical Name:1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5- yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-
CAS No.:874502-50-8
Molecular Formula:C₂₉H₂₈F₉N₇O₂
Molecular Weight:677.573
Hs Code.:

1(2H)-Quinolinecarboxylic acid,
4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5-
yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester,
(2R,4S)-

Synonyms:

Suppliers and Price of 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5- yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5- yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5- yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)-

There total 9 articles about 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][2-(2-cyanoethyl)-2H-tetrazol-5- yl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, 1-methylethyl ester, (2R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874501-94-7
C₂₆H₂₅F₉N₆O₂

: 874502-50-8
C₂₉H₂₈F₉N₇O₂

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃;
DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

: (3R)-[3-(4-trifluoromethylphenylamino)pentanoyl]carbamic acid benzyl ester

: 874502-50-8
C₂₉H₂₈F₉N₇O₂

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate; magnesium chloride / ethanol; water

2: pyridine / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr

4: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

6: sodium azide; triethylamine / toluene / 110 °C

7: potassium carbonate / N,N-dimethyl-formamide; acetone / 20 °C

With pyridine; sodium tetrahydroborate; sodium azide; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; magnesium chloride; In tetrahydrofuran; 1,1-dichloroethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.bmcl.2012.04.042

Reference yield:

: 474645-96-0
(2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester

: 874502-50-8
C₂₉H₂₈F₉N₇O₂

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 760.05 Torr

3: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5: sodium azide; triethylamine / toluene / 110 °C

6: potassium carbonate / N,N-dimethyl-formamide; acetone / 20 °C

With pyridine; sodium azide; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,1-dichloroethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.bmcl.2012.04.042