Heptanedioic acid, 2-methylene-6-[[(phenylmethoxy)carbonyl]amino]-, 1-[2-[(1S)-1-(3-amino-3,4-dihydro-4-oxo-2-quinazolinyl)ethoxy]ethyl] 7-methyl ester, (6S)-

Base Information

Chemical Name:Heptanedioic acid, 2-methylene-6-[[(phenylmethoxy)carbonyl]amino]-, 1-[2-[(1S)-1-(3-amino-3,4-dihydro-4-oxo-2-quinazolinyl)ethoxy]ethyl] 7-methyl ester, (6S)-
CAS No.:874534-93-7
Molecular Formula:C29H34N4O8
Molecular Weight:566.611
Hs Code.:

Heptanedioic acid, 2-methylene-6-[[(phenylmethoxy)carbonyl]amino]-,
1-[2-[(1S)-1-(3-amino-3,4-dihydro-4-oxo-2-quinazolinyl)ethoxy]ethyl]
7-methyl ester, (6S)-

Synonyms:

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Chemical Property of Heptanedioic acid, 2-methylene-6-[[(phenylmethoxy)carbonyl]amino]-, 1-[2-[(1S)-1-(3-amino-3,4-dihydro-4-oxo-2-quinazolinyl)ethoxy]ethyl] 7-methyl ester, (6S)-

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Technology Process of Heptanedioic acid, 2-methylene-6-[[(phenylmethoxy)carbonyl]amino]-, 1-[2-[(1S)-1-(3-amino-3,4-dihydro-4-oxo-2-quinazolinyl)ethoxy]ethyl] 7-methyl ester, (6S)-

There total 6 articles about Heptanedioic acid, 2-methylene-6-[[(phenylmethoxy)carbonyl]amino]-, 1-[2-[(1S)-1-(3-amino-3,4-dihydro-4-oxo-2-quinazolinyl)ethoxy]ethyl] 7-methyl ester, (6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 3-amino-2-[1-(2-hydroxy-ethoxy)-ethyl]-3H-quinazolin-4-one

: 874534-90-4
(2S)-2-benzyloxycarbonylamino-6-methylene-heptanedioic acid 1-methyl ester

: 874534-93-7
(2S)-2-benzyloxycarbonylamino-6-methylene-heptanedioic acid 7-{(2S)-2-[1-(3-amino-4-oxo-3,4-dihydroquinazolin-2-yl)ethoxy]-ethyl} ester 1-methyl ester

Guidance literature:: With dmap; polymer-bound N-benzyl-N'-cyclohexylcarbodiimide; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1039/b513409a

Reference yield:

: 874534-85-7
dimethyl (2S)-N-benzyloxycarbonyl-2-amino-6-methylhept-6-ene-dioate

: 874534-93-7
(2S)-2-benzyloxycarbonylamino-6-methylene-heptanedioic acid 7-{(2S)-2-[1-(3-amino-4-oxo-3,4-dihydroquinazolin-2-yl)ethoxy]-ethyl} ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / aq. LiOH / methanol / 16 h / 20 °C

2: 95 percent / polymer-bound p-toluenesulfonic acid / 16 h / 20 °C

3: 51 percent / polymer-bound N-benzyl-N'-cyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 48 h / 20 °C

With dmap; lithium hydroxide; polymer-bound N-benzyl-N'-cyclohexylcarbodiimide; polymer-bound p-toluenesulfonic acid; In methanol; dichloromethane;
DOI:10.1039/b513409a

Reference yield:

: 874535-03-2
(2S)-2-benzyloxycarbonylamino-6-methylene-heptanedioic acid

: 874534-93-7
(2S)-2-benzyloxycarbonylamino-6-methylene-heptanedioic acid 7-{(2S)-2-[1-(3-amino-4-oxo-3,4-dihydroquinazolin-2-yl)ethoxy]-ethyl} ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / polymer-bound p-toluenesulfonic acid / 16 h / 20 °C

2: 51 percent / polymer-bound N-benzyl-N'-cyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 48 h / 20 °C

With dmap; polymer-bound N-benzyl-N'-cyclohexylcarbodiimide; polymer-bound p-toluenesulfonic acid; In dichloromethane;
DOI:10.1039/b513409a