Technology Process of Benzoic acid,
4-[[[1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclobutyl]carbonyl]amino]-2
,6-dimethoxy-, methyl ester
There total 1 articles about Benzoic acid,
4-[[[1-[[(1,1-dimethylethoxy)carbonyl]amino]cyclobutyl]carbonyl]amino]-2
,6-dimethoxy-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-amino-2,6-dimethoxybenzoate; 1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dimethyl sulfoxide;
at 20 ℃;
for 24h;
With
acetic acid;
In
water; dimethyl sulfoxide;
- Guidance literature:
-
C20H28N2O7;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3.5h;
With
acetic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere
2.1: manganese(IV) oxide / tetrahydrofuran / 24 h / Reflux; Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere
6.1: sodium hydroxide / dimethyl sulfoxide; methanol / 2 h / 20 °C / Inert atmosphere
6.2: Inert atmosphere
With
hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; mineral oil;
3.2: |Wittig-Horner Reaction;
DOI:10.1021/jm501532z
