2,4(1H,3H)-Pyrimidinedione, 3-[(4-methoxyphenyl)methyl]-5-methyl-1-[(1R,3R,4S,5R)-4-(phenylmeth oxy)-3-[(phenylmethoxy)methyl]-2-oxa-6-azabicyclo[3.2.0]hept-1-yl]-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 3-[(4-methoxyphenyl)methyl]-5-methyl-1-[(1R,3R,4S,5R)-4-(phenylmeth oxy)-3-[(phenylmethoxy)methyl]-2-oxa-6-azabicyclo[3.2.0]hept-1-yl]-
CAS No.:874812-39-2
Molecular Formula:C33H35N3O6
Molecular Weight:569.657
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
3-[(4-methoxyphenyl)methyl]-5-methyl-1-[(1R,3R,4S,5R)-4-(phenylmeth
oxy)-3-[(phenylmethoxy)methyl]-2-oxa-6-azabicyclo[3.2.0]hept-1-yl]-

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 3-[(4-methoxyphenyl)methyl]-5-methyl-1-[(1R,3R,4S,5R)-4-(phenylmeth oxy)-3-[(phenylmethoxy)methyl]-2-oxa-6-azabicyclo[3.2.0]hept-1-yl]-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 3-[(4-methoxyphenyl)methyl]-5-methyl-1-[(1R,3R,4S,5R)-4-(phenylmeth oxy)-3-[(phenylmethoxy)methyl]-2-oxa-6-azabicyclo[3.2.0]hept-1-yl]-

There total 10 articles about 2,4(1H,3H)-Pyrimidinedione, 3-[(4-methoxyphenyl)methyl]-5-methyl-1-[(1R,3R,4S,5R)-4-(phenylmeth oxy)-3-[(phenylmethoxy)methyl]-2-oxa-6-azabicyclo[3.2.0]hept-1-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 874812-37-0
Methanesulfonic acid (2R,3S,4R,5R)-2-aminomethyl-4-benzyloxy-5-benzyloxymethyl-2-[3-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

: 874812-39-2
(1R,3R,4S,5R)-3-benzyloxymethyl-4-benzyloxy-1-(3-N-(4-methoxybenzyl)thymin-1-yl)-6-aza-2-oxabicyclo[3.2.0]heptane

Guidance literature:: With pyridine; triethylamine; at 90 ℃; for 48h;
DOI:10.1021/jo052115x

Reference yield:

: 1054657-53-2
(2R,3R,3aS,9aR)-3-Benzyloxy-2-benzyloxymethyl-9a-hydroxymethyl-7-methyl-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one

: 874812-39-2
(1R,3R,4S,5R)-3-benzyloxymethyl-4-benzyloxy-1-(3-N-(4-methoxybenzyl)thymin-1-yl)-6-aza-2-oxabicyclo[3.2.0]heptane

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3.26 g / aq. NaOH / ethanol / 20 °C

2.1: 98 percent / pyridine / 3 h / 20 °C

3.1: 80 percent / NaH / dimethylformamide / 0 - 20 °C

4.1: 94 percent / MeONa / methanol / 0.5 h / 20 °C

5.1: pyridine / 0 - 4 °C

5.2: 77 percent / dimethylformamide / 110 °C

6.1: 93 percent / aq. MeNH₂ / methanol / 4 h / 20 °C

7.1: 66 percent / Et₃N; pyridine / 48 h / 90 °C

With pyridine; sodium hydroxide; sodium methylate; sodium hydride; triethylamine; methylamine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo052115x

Reference yield:

: 874812-33-6
1-((2R,3S,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: 874812-39-2
(1R,3R,4S,5R)-3-benzyloxymethyl-4-benzyloxy-1-(3-N-(4-methoxybenzyl)thymin-1-yl)-6-aza-2-oxabicyclo[3.2.0]heptane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / pyridine / 3 h / 20 °C

2.1: 80 percent / NaH / dimethylformamide / 0 - 20 °C

3.1: 94 percent / MeONa / methanol / 0.5 h / 20 °C

4.1: pyridine / 0 - 4 °C

4.2: 77 percent / dimethylformamide / 110 °C

5.1: 93 percent / aq. MeNH₂ / methanol / 4 h / 20 °C

6.1: 66 percent / Et₃N; pyridine / 48 h / 90 °C

With pyridine; sodium methylate; sodium hydride; triethylamine; methylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo052115x