N-BOC-L-VALINYL-L-LEUCINYL ANILIDE

Base Information

• Chemical Name: N-BOC-L-VALINYL-L-LEUCINYL ANILIDE
• CAS No.: 874899-05-5
• Molecular Formula: C22H35N3O4
• Molecular Weight: 405.53100
• Mol file: 874899-05-5.mol

Synonyms:N-Boc-L-valinyl-L-leucinyl Anilide;

Chemical Property of N-BOC-L-VALINYL-L-LEUCINYL ANILIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 124-130°C
• PSA: 107.00000
• LogP: 5.39950
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

N-Boc-L-valinyl-L-leucinylAnilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-L-VALINYL-L-LEUCINYL ANILIDE

There total 4 articles about N-BOC-L-VALINYL-L-LEUCINYL ANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

t-Boc-L-valine (13734-41-3) + L-leucine, N-phenylamine hydrochloride → N-tert-butoxycarbonylvalylleucyl anilide (874899-05-5)

Guidance literature:

t-Boc-L-valine; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

L-leucine, N-phenylamine hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1002/ejoc.200500429

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → N-tert-butoxycarbonylvalylleucyl anilide (874899-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HOAt; iPr₂NEt; EDC*HCl / CH₂Cl₂ / 1 h / 0 °C

1.2: 65 percent / CH₂Cl₂ / 20 °C

2.1: 98 percent / hydrogen chloride / CH₂Cl₂; ethyl acetate

3.1: HOAt; iPr₂NEt; EDC*HCl / CH₂Cl₂ / 1 h / 0 °C

3.2: 91 percent / CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;

DOI:10.1002/ejoc.200500429

Reference yield:

aniline (62-53-3) → N-tert-butoxycarbonylvalylleucyl anilide (874899-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HOAt; iPr₂NEt; EDC*HCl / CH₂Cl₂ / 1 h / 0 °C

1.2: 65 percent / CH₂Cl₂ / 20 °C

2.1: 98 percent / hydrogen chloride / CH₂Cl₂; ethyl acetate

3.1: HOAt; iPr₂NEt; EDC*HCl / CH₂Cl₂ / 1 h / 0 °C

3.2: 91 percent / CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;

DOI:10.1002/ejoc.200500429

upstream raw materials:

t-Boc-L-valine

N-tert-butoxycarbonyl-L-leucine

aniline

tert-butyl (4-methyl-1-oxo-1-(phenylamino)pentan-2-yl)carbamate

Downstream raw materials:

N-(3-chloro-2-hydroxypropyl)valylleucyl anilide

N-benzylvalylleucyl anilide

N-(2-cyanoethyl)valylleucyl anilide

valylleucyl anilide