Acetamide, N-[4-(hydroxymethyl)-5-[[3-(methylthio)phenyl]methyl]-2-thiazolyl]-

Base Information

Chemical Name:Acetamide, N-[4-(hydroxymethyl)-5-[[3-(methylthio)phenyl]methyl]-2-thiazolyl]-
CAS No.:874899-40-8
Molecular Formula:C14H16N2O2S2
Molecular Weight:308.425
Hs Code.:

Synonyms:

Suppliers and Price of Acetamide, N-[4-(hydroxymethyl)-5-[[3-(methylthio)phenyl]methyl]-2-thiazolyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetamide, N-[4-(hydroxymethyl)-5-[[3-(methylthio)phenyl]methyl]-2-thiazolyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetamide, N-[4-(hydroxymethyl)-5-[[3-(methylthio)phenyl]methyl]-2-thiazolyl]-

There total 9 articles about Acetamide, N-[4-(hydroxymethyl)-5-[[3-(methylthio)phenyl]methyl]-2-thiazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874899-39-5
ethyl 2-(acetylamino)-5-[3-(methylthio)benzyl]-1,3-thiazole-4-carboxylate

: 874899-40-8
N-{4-(hydroxymethyl)-5-[3-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: ethyl 2-(acetylamino)-5-[3-(methylthio)benzyl]-1,3-thiazole-4-carboxylate; With lithium borohydride; In tetrahydrofuran; at 0 ℃; for 10h; Heating / reflux;

With sodium sulfate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 73771-35-4
3-(methylsulfanyl)benzaldehyde

: 874899-40-8
N-{4-(hydroxymethyl)-5-[3-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / Reflux

2.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 9 h / 20 °C / 3040.2 Torr

3.1: sodium methylate / methanol / 0 - 65 °C

3.2: 15 h / Reflux

3.3: 2 h / Reflux

4.1: copper(ll) bromide / ethyl acetate; chloroform / 13 h / Reflux

5.1: ethanol / 2 h / Reflux; Inert atmosphere

6.1: pyridine / 0 - 50 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium methylate; diisobutylaluminium hydride; acetic acid; copper(ll) bromide; In tetrahydrofuran; methanol; ethanol; chloroform; ethyl acetate; 1.1: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 825-99-0
3-methylsulfanyl-benzoic acid

: 874899-40-8
N-{4-(hydroxymethyl)-5-[3-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 3.17 h / -78 - 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / Reflux

4.1: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 9 h / 20 °C / 3040.2 Torr

5.1: sodium methylate / methanol / 0 - 65 °C

5.2: 15 h / Reflux

5.3: 2 h / Reflux

6.1: copper(ll) bromide / ethyl acetate; chloroform / 13 h / Reflux

7.1: ethanol / 2 h / Reflux; Inert atmosphere

8.1: pyridine / 0 - 50 °C / Inert atmosphere

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium methylate; diisobutylaluminium hydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; copper(ll) bromide; In tetrahydrofuran; methanol; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; 3.1: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048