Phospholo[3,4-c]pyrrol-5-amine, octahydro-N,N-bis(1-methylethyl)-2-(phenylmethyl)-, 5-oxide

Base Information

• Chemical Name: Phospholo[3,4-c]pyrrol-5-amine, octahydro-N,N-bis(1-methylethyl)-2-(phenylmethyl)-, 5-oxide
• CAS No.: 875138-24-2
• Molecular Formula: C19H31N2OP
• Molecular Weight: 334.442
• Mol file: 875138-24-2.mol

Synonyms:

Chemical Property of Phospholo[3,4-c]pyrrol-5-amine, octahydro-N,N-bis(1-methylethyl)-2-(phenylmethyl)-, 5-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phospholo[3,4-c]pyrrol-5-amine, octahydro-N,N-bis(1-methylethyl)-2-(phenylmethyl)-, 5-oxide

There total 1 articles about Phospholo[3,4-c]pyrrol-5-amine, octahydro-N,N-bis(1-methylethyl)-2-(phenylmethyl)-, 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N,N-diisopropylphosphoramide dichloride (921-26-6) + N,N-di-2-propenylbenzylamine (4383-26-0) → (2-benzyl-5-oxo-octahydro-2-aza-5λ5-phospha-pentalen-5-yl)-diisopropyl-amine (875138-24-2)

Guidance literature:

N,N-diisopropylphosphoramide dichloride; With aluminium trichloride; In dichloromethane; at 20 ℃; for 1h;

N,N-di-2-propenylbenzylamine; In dichloromethane; for 17h;

With ethylenediaminetetraacetic acid; sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1055/s-2005-921902

Reference yield: 73.0%

(2-benzyl-5-oxo-octahydro-2-aza-5λ5-phospha-pentalen-5-yl)-diisopropyl-amine (875138-24-2) → (3aS,6aR)-2-Benzyl-5-oxo-octahydro-2-aza-5λ5-phospha-pentalen-5-ol (875138-26-4)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1055/s-2005-921902

upstream raw materials:

N,N-diisopropylphosphoramide dichloride

N,N-di-2-propenylbenzylamine

Downstream raw materials:

(3aS,6aR)-2-Benzyl-5-oxo-octahydro-2-aza-5λ⁵-phospha-pentalen-5-ol