1-Piperidinecarboxylic acid, 2-[[[(1S)-2-(1,1-dimethylethoxy)-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl] amino]carbonyl]-, phenylmethyl ester, (2S)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 2-[[[(1S)-2-(1,1-dimethylethoxy)-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl] amino]carbonyl]-, phenylmethyl ester, (2S)-
CAS No.:875151-92-1
Molecular Formula:C27H34N2O6
Molecular Weight:482.577
Hs Code.:

1-Piperidinecarboxylic acid,
2-[[[(1S)-2-(1,1-dimethylethoxy)-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl]
amino]carbonyl]-, phenylmethyl ester, (2S)-

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 2-[[[(1S)-2-(1,1-dimethylethoxy)-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl] amino]carbonyl]-, phenylmethyl ester, (2S)-

Chemical Property:

Purity/Quality:

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Technology Process of 1-Piperidinecarboxylic acid, 2-[[[(1S)-2-(1,1-dimethylethoxy)-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl] amino]carbonyl]-, phenylmethyl ester, (2S)-

There total 1 articles about 1-Piperidinecarboxylic acid, 2-[[[(1S)-2-(1,1-dimethylethoxy)-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl] amino]carbonyl]-, phenylmethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 16874-12-7,87553-74-0
Tyr(tBu)

: 28697-11-2
(S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid

: 875151-92-1
(S)-2-[(S)-1-tert-butoxycarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Tyr(tBu); With 1-methyl-1H-imidazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,2-dichloro-ethane; at 20 ℃; for 0.333333h;

(S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid; In 1,2-dichloro-ethane; at 20 ℃; for 48h;

Reference yield:

: 875151-92-1
(S)-2-[(S)-1-tert-butoxycarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester

: (S)-1-(3-fluoro-benzenesulfonyl)-piperidine-2-carboxylic acid [(S)-2-(4-methoxy-phenyl)-1-(tetrahydro-pyran-4-ylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 96 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C / 3361.55 - 3620.13 Torr

3.1: triethylamine / 1,2-dichloro-ethane / 18 h / 20 - 50 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: 1-methyl-1H-imidazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 1,2-dichloro-ethane / 0.33 h / 20 °C

5.2: 48 h / 20 °C

With 1-methyl-1H-imidazole; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 875151-92-1
(S)-2-[(S)-1-tert-butoxycarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester

: 875151-94-3
(S)-3-(4-methoxy-phenyl)-2-[((S)-piperidine-2-carbonyl)-amino]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 96 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C / 3361.55 - 3620.13 Torr

With hydrogen; caesium carbonate; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;