2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one

Base Information

Chemical Name:2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one
CAS No.:87532-40-9
Molecular Formula:C14H13NO2S
Molecular Weight:259.32400
Hs Code.:
DSSTox Substance ID:DTXSID90708967

Synonyms:87532-40-9;DTXSID90708967;2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one

Suppliers and Price of 2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one

Chemical Property:

PSA：75.49000
LogP:2.71980
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:259.06669983
Heavy Atom Count:18
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CSC1=CC=C(C=C1)C(=O)C(C2=CC=NC=C2)O

Technology Process of 2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one

There total 2 articles about 2-Hydroxy-1-[4-(methylsulfanyl)phenyl]-2-(pyridin-4-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72873-67-7
1-(benzoyloxy)-1-(4-pyridyl)acetonitrile

: 3446-89-7
4-(Methylthio)benzaldehyde

: 87532-40-9
1-<(4-methylthio)phenyl>-2-hydroxy-2-(4-pyridyl)ethanone

: 87532-37-4
1-(4-pyridyl)-2-(4-methoxyphenyl)-2-(benzyloxy)ethanone

Guidance literature:: With potassium hydride; In tert-butyl alcohol; for 1.5h; Ambient temperature;
DOI:10.1021/jm00367a014

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 87532-40-9
1-<(4-methylthio)phenyl>-2-hydroxy-2-(4-pyridyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / benzyltrimethylammonium chloride / CH₂Cl₂; H₂O

2: 65 percent / KH / 2-methyl-propan-2-ol / 1.5 h / Ambient temperature

With benzyltrimethylammonium chloride; potassium hydride; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm00367a014

Reference yield:

: 87532-40-9
1-<(4-methylthio)phenyl>-2-hydroxy-2-(4-pyridyl)ethanone

: 72873-72-4
6-(4-methylthiophenyl)-5-(pyridin-4-yl)-2,3-dihydro-imidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / dimethylformamide / 4 h / Heating

2: 1.) NaH, 2.) K₂CO₃ / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00367a014