(5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one

Base Information

Chemical Name:(5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one
CAS No.:127882-81-9
Molecular Formula:C27H23 F O8
Molecular Weight:494.4651
Hs Code.:
Mol file:127882-81-9.mol

(5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one

Synonyms:Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,9-(4-fluorophenoxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-,[5R-(5a,5ab,8aa,9b)]-

Suppliers and Price of (5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one

Chemical Property:

Vapor Pressure:6.23E-19mmHg at 25°C
Boiling Point:676.7°Cat760mmHg
Flash Point:363.1°C
Density:1.398g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

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Technology Process of (5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one

There total 3 articles about (5S,5aR,8aR,9R)-5-(4-fluorophenoxy)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofurano[5,6-f][1,3]benzodioxol-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127882-52-4
Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-(4-fluoro-phenoxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

: 127882-81-9
4'-O-demethyl-4β-(4''-fluorophenyl)podophyllotoxin

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm00171a050

Reference yield:

: 23363-33-9
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

: 127882-81-9
4'-O-demethyl-4β-(4''-fluorophenyl)podophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*Et₂O / 1,2-dichloro-ethane / 1 h / -15 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 2 h / Ambient temperature

With boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jm00171a050

Reference yield:

: 371-41-5
4-Fluorophenol

: 127882-81-9
4'-O-demethyl-4β-(4''-fluorophenyl)podophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*Et₂O / 1,2-dichloro-ethane / 1 h / -15 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 2 h / Ambient temperature

With boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jm00171a050