sophoflavescenol

Base Information

• Chemical Name: sophoflavescenol
• CAS No.: 216450-65-6
• Molecular Formula: C21H20O6
• Molecular Weight: 368.38
• Mol file: 216450-65-6.mol

Synonyms:

Chemical Property of sophoflavescenol

Chemical Property:

• Melting Point: 273-275 °C
• Boiling Point: 631.8±55.0 °C(Predicted)
• PKA: 7.03±0.40(Predicted)
• PSA: 100.13000
• Density: 1.359±0.06 g/cm3(Predicted)
• LogP: 4.09410

Purity/Quality:

≥98% ^*data from raw suppliers

Sophoflavescenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sophoflavescenol

There total 11 articles about sophoflavescenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7,8-(2,2-dimethyl-2H-pyran)-5,4'-dihydroxyflavonol → 8-prenyl-3,7,4'-trihydroxy-5-methoxyflavone (216450-65-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 2h;

DOI:10.1002/ejoc.201403689

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 8-prenyl-3,7,4'-trihydroxy-5-methoxyflavone (216450-65-6)

Guidance literature:

Multi-step reaction with 10 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: potassium hydroxide / ethanol / 48 h / 20 °C

3.1: iodine / dimethyl sulfoxide / 24 h / Reflux

4.1: Oxone; sodium carbonate; sodium hydrogencarbonate / dichloromethane; acetone / 5 h / 0 °C

4.2: 0.5 h / 20 °C

5.1: hydrogenchloride / ethanol; water / 0.5 h / 20 °C

6.1: potassium carbonate / acetone / 0.5 h / 20 °C

6.2: 2 h / 20 °C

7.1: potassium carbonate / acetone / 1 h / 20 °C

7.2: 5 h / 50 °C

8.1: N,N-diethylaniline / 0.75 h / 190 °C / Microwave irradiation; Inert atmosphere

9.1: sodium hydroxide / 5 h / 20 °C / pH 9 - 10

10.1: hydrogenchloride / ethanol; water / 2 h

With hydrogenchloride; Oxone; iodine; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; N,N-diethylaniline; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide; acetone;

DOI:10.1002/ejoc.201403689

Reference yield:

5-hydroxy-8-prenyl-3,4',7-tris-O-methoxymethylkaempferol (143724-76-9) → 8-prenyl-3,7,4'-trihydroxy-5-methoxyflavone (216450-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 5 h / 20 °C / pH 9 - 10

2: hydrogenchloride / ethanol; water / 2 h

With hydrogenchloride; sodium hydroxide; In ethanol; water;

DOI:10.1002/ejoc.201403689

upstream raw materials:

5-hydroxy-8-prenyl-3,4',7-tris-O-methoxymethylkaempferol

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

2,4,6-trihydroxyacetophenone

4-methoxymethoxy-benzaldehyde