Technology Process of Carbamic acid,
[3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[
5,4-d]pyrimidin-6-yl]-2-methylpropyl](4-methylbenzoyl)amino]propyl]-,
1,1-dimethylethyl ester
There total 12 articles about Carbamic acid,
[3-[[1-[5-[(3-fluorophenyl)methyl]-4,5-dihydro-3-methyl-4-oxoisothiazolo[
5,4-d]pyrimidin-6-yl]-2-methylpropyl](4-methylbenzoyl)amino]propyl]-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ammonium hydroxide; dihydrogen peroxide / water / 16 h / 60 °C
2.1: ammonium hydroxide / 5 h / 140 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
4.1: bromine; sodium acetate; acetic acid / 0.83 h / 100 °C
5.1: sodium azide / N,N-dimethyl-formamide / 1 h / 25 °C
6.1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C
7.1: dichloromethane / 3 h / 25 °C / Molecular sieve
7.2: 16 h / 25 °C / Molecular sieve
8.1: pyridine / 48 h / 25 °C
With
pyridine; ammonium hydroxide; sodium azide; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; bromine; sodium acetate; potassium carbonate; acetic acid;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
6.1: Staudinger reaction;
DOI:10.1021/jm200629m
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium hydroxide / 5 h / 140 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
3.1: bromine; sodium acetate; acetic acid / 0.83 h / 100 °C
4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 25 °C
5.1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C
6.1: dichloromethane / 3 h / 25 °C / Molecular sieve
6.2: 16 h / 25 °C / Molecular sieve
7.1: pyridine / 48 h / 25 °C
With
pyridine; ammonium hydroxide; sodium azide; 5%-palladium/activated carbon; hydrogen; bromine; sodium acetate; potassium carbonate; acetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
5.1: Staudinger reaction;
DOI:10.1021/jm200629m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
2.1: bromine; sodium acetate; acetic acid / 0.83 h / 100 °C
3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 25 °C
4.1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C
5.1: dichloromethane / 3 h / 25 °C / Molecular sieve
5.2: 16 h / 25 °C / Molecular sieve
6.1: pyridine / 48 h / 25 °C
With
pyridine; sodium azide; 5%-palladium/activated carbon; hydrogen; bromine; sodium acetate; potassium carbonate; acetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: Staudinger reaction;
DOI:10.1021/jm200629m
