2-(4-Aminophenyl)ethylamine

Base Information

• Chemical Name: 2-(4-Aminophenyl)ethylamine
• CAS No.: 13472-00-9
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• Hs Code.: 29215900
• European Community (EC) Number: 236-739-2
• NSC Number: 299558
• UNII: X34DV3E856
• DSSTox Substance ID: DTXSID30158902
• Nikkaji Number: J264J
• Wikidata: Q72440589
• ChEMBL ID: CHEMBL1650241
• Mol file: 13472-00-9.mol

Synonyms:2-(4-aminophenyl)ethylamine;4-aminophenethylamine

Chemical Property of 2-(4-Aminophenyl)ethylamine

Chemical Property:

• Appearance/Colour: Light yellow solid or liquid
• Vapor Pressure: 0.000485mmHg at 25°C
• Melting Point: 28-31 °C(lit.)
• Refractive Index: n20/D 1.591(lit.)
• Boiling Point: 313.8 °C at 760 mmHg
• PKA: 10.32±0.10(Predicted)
• Flash Point: 140.9 °C
• PSA: 52.04000
• Density: 1.062 g/cm³
• LogP: 2.05150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: Insoluble in water.
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

99% ^*data from raw suppliers

Aminophenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 34-20/21/22
• Safety Statements: 26-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCN)N
• Uses: 4-(2-Aminoethyl)aniline has been used in chemical modification of silk fibroin to tailor the overall hydrophilicity and structure of silk. It has been used as reagent in polycondensation reactions.

Technology Process of 2-(4-Aminophenyl)ethylamine

There total 28 articles about 2-(4-Aminophenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-aminophenylacetonitrile (3544-25-0) → p-Aminophenethylamine (13472-00-9)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; at 50 - 55 ℃;

DOI:10.1016/S0040-4039(01)81568-9

Reference yield: 86.0%

1-nitro-4-(2-nitroethyl)benzene (21473-45-0) → p-Aminophenethylamine (13472-00-9)

Guidance literature:

With samarium diiodide; water; isopropylamine; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.05.105

Reference yield: 77.0%

4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) → p-Aminophenethylamine (13472-00-9)

Guidance literature:

With sodium tetrahydroborate; (-); In ethanol; at 20 ℃; for 156h;

upstream raw materials:

p-aminophenylacetonitrile

2-(p-nitrophenyl)ethylamine

N-<2-(4-nitrophenyl)ethyl>phthalimide

4-(2-(((methyl)carbonyl)amino)ethyl)aniline

Downstream raw materials:

tyrosamine

4-(2-amino-ethyl)-cyclohexylamine

(4-amino-phenethyl)-cyclohexyl-amine

triethyl-(4-triethylammonio-phenethyl)-ammonium; diiodide

Refernces

• 1、 Liu, Da-Ying,Qi, Jing,Liu, Xiao-Yan,He, Hua-Rui,Chen, Jia-Tong,Yang, Guang-Ming. "4-Amino-1,8-naphthalimide-based fluorescent sensor with high selectivity and sensitivity for Zn2 + imaging in living cells". . p. 173 - 178. Retrieved 2014.
• 2、 Prousis, Kyriakos C.,Canton-Vitoria, Ruben,Pagona, Georgia,Goulielmaki, Maria,Zoumpourlis, Vassilis,Tagmatarchis, Nikos,Calogeropoulou, Theodora. "New cationic heptamethinecyanine-graphene hybrid materials". . . Retrieved 2019/12/27.
• 3、 -. "A process for preparing a broad pH fluorescent probe of the organic compound and use thereof (by machine translation)". . . Retrieved 2018/04/03.