Benzoic acid, 2-fluoro-, 3-[[2-(acetylamino)-1,1-dimethylethyl]amino]-2-hydroxypropyl ester

Base Information

• Chemical Name: Benzoic acid, 2-fluoro-, 3-[[2-(acetylamino)-1,1-dimethylethyl]amino]-2-hydroxypropyl ester
• CAS No.: 87721-53-7
• Molecular Formula: C₁₆H₂₃FN₂O₄
• Molecular Weight: 326.368
• Mol file: 87721-53-7.mol

Synonyms:

Chemical Property of Benzoic acid, 2-fluoro-, 3-[[2-(acetylamino)-1,1-dimethylethyl]amino]-2-hydroxypropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-fluoro-, 3-[[2-(acetylamino)-1,1-dimethylethyl]amino]-2-hydroxypropyl ester

There total 2 articles about Benzoic acid, 2-fluoro-, 3-[[2-(acetylamino)-1,1-dimethylethyl]amino]-2-hydroxypropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

1,1-dimethyl-2-(methylcarbonylamino)ethylamine (87484-88-6) + 2,3-epoxypropyl o-fluorobenzoate (85515-51-1) → 3-[1,1-dimethyl-2-(methylcarbonylamino)]ethylamino-2-hydroxypropyl 2-fluorobenzoate (87721-53-7)

Guidance literature:

In N,N-dimethyl-formamide; Heating;

DOI:10.1021/jm00374a013

Reference yield:

2-Fluorobenzoyl chloride (393-52-2) → 3-[1,1-dimethyl-2-(methylcarbonylamino)]ethylamino-2-hydroxypropyl 2-fluorobenzoate (87721-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.2 percent / Et₃N / diethyl ether / 2 h / Ambient temperature

2: 10 percent / dimethylformamide / Heating

With triethylamine; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm00374a013

upstream raw materials:

1,1-dimethyl-2-(methylcarbonylamino)ethylamine

2,3-epoxypropyl o-fluorobenzoate

2-Fluorobenzoyl chloride

Refernces