1-BOC-6-BROMO-INDAZOLE

Base Information

• Chemical Name: 1-BOC-6-BROMO-INDAZOLE
• CAS No.: 877264-77-2
• Molecular Formula: C12H13BrN2O2
• Molecular Weight: 297.151
• Hs Code.: 2933990090
• Mol file: 877264-77-2.mol

Synonyms:1-Boc-6-bromo-1H-indazole;1-BOC-6-BROMO-INDAZOLE;1-([1,1-dimethylethyl]oxycarbonyl)-6-bromoindazole;6-Bromo-1H-indazole,N1-BOC protected;1,1-dimethylethyl 6-bromo-1H-indazole-1-carboxylate;

Chemical Property of 1-BOC-6-BROMO-INDAZOLE

Chemical Property:

• Boiling Point: 377oC
• Flash Point: 182oC
• PSA: 44.12000
• Density: 1.46
• LogP: 3.58200
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl6-Bromo-1H-indazole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-6-BROMO-INDAZOLE

There total 3 articles about 1-BOC-6-BROMO-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 1,1-dimethylethyl 6-bromo-1H-indazole-1-carboxylate (877264-77-2)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 20 ℃; for 3.25h; Inert atmosphere;

Reference yield: 94.0%

6-bromo-1H-indazole (79762-54-2) + di-tert-butyl dicarbonate (24424-99-5) → 1,1-dimethylethyl 6-bromo-1H-indazole-1-carboxylate (877264-77-2)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 0 - 20 ℃; for 18h;

Reference yield:

→ 2-([1,1-dimethylethyloxy]carbonyl)-6-bromoindazole + 1,1-dimethylethyl 6-bromo-1H-indazole-1-carboxylate (877264-77-2)

Guidance literature:

upstream raw materials:

6-bromo-1H-indazole

di-tert-butyl dicarbonate

Downstream raw materials:

1,1-dimethylethyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate

4-(1H-indazol-6-yl)benzaldehyde

N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4-(1H-indazol-6-yl)-N-methylbenzamide

N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4-(1H-indazyl)benzamide

Refernces

• 1、 -. "2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE". Paragraph 0149; 0154. . Retrieved 2015/11/27.
• 2、 -. "FATTY ACID SYNTHASE INHIBITORS". Page/Page column 49. . Retrieved 2012/04/04.