2-(4-Chlorophenyl)-1-(phenylsulfonyl)azetidine

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-1-(phenylsulfonyl)azetidine
• CAS No.: 87751-36-8
• Molecular Formula: C₁₅H₁₄ClNO₂S
• Molecular Weight: 307.801
• DSSTox Substance ID: DTXSID70515914
• Nikkaji Number: J968.689D
• Mol file: 87751-36-8.mol

Synonyms:2-(4-Chlorophenyl)-1-(phenylsulfonyl)azetidine;87751-36-8;1-(Benzenesulfonyl)-2-(4-chlorophenyl)azetidine;DTXSID70515914

Chemical Property of 2-(4-Chlorophenyl)-1-(phenylsulfonyl)azetidine

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 307.0433776
• Heavy Atom Count: 20
• Complexity: 420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(C1C2=CC=C(C=C2)Cl)S(=O)(=O)C3=CC=CC=C3

Technology Process of 2-(4-Chlorophenyl)-1-(phenylsulfonyl)azetidine

There total 4 articles about 2-(4-Chlorophenyl)-1-(phenylsulfonyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

trimethyl sulfoxonium chloride (5034-06-0) + 2-(4-chlorophenyl)-1-phenylsulfonylaziridine (137152-08-0) → 1-Benzenesulfonyl-2-(4-chloro-phenyl)-azetidine (87751-36-8) + C29H26Cl2N2O4S2 + C29H26Cl2N2O4S2

Guidance literature:

With 18-crown-6 ether; potassium tert-butylate; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield: 21.0%

N-(4-chlorobenzylidene)benzenesulfonamide (87751-37-9) + dimethylsulfoxonium methylide (70775-39-2,5367-24-8) → 1-Benzenesulfonyl-2-(4-chloro-phenyl)-azetidine (87751-36-8)

Guidance literature:

In dimethyl sulfoxide; for 15h; Ambient temperature;

DOI:10.1055/s-1983-30421

Reference yield: 18.0%

2-(4-chlorophenyl)-1-phenylsulfonylaziridine (137152-08-0) + dimethylsulfoxonium methylide (70775-39-2,5367-24-8) → 1-Benzenesulfonyl-2-(4-chloro-phenyl)-azetidine (87751-36-8)

Guidance literature:

In dimethyl sulfoxide; for 20h; Ambient temperature;

upstream raw materials:

N-(4-chlorobenzylidene)benzenesulfonamide

dimethylsulfoxonium methylide

2-(4-chlorophenyl)-1-phenylsulfonylaziridine

trimethylsulfoxonium iodide