Technology Process of 3-amino-2-phenyl-2,3-dihydro-4H-chromen-4-one
There total 6 articles about 3-amino-2-phenyl-2,3-dihydro-4H-chromen-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N‐{[(4‐methylphenyl)sulfonyl]oxy}‐2‐phenyl‐2,3‐dihydro‐4H‐chromen‐4‐imine;
With
sodium ethanolate;
In
toluene;
at 20 ℃;
for 24h;
Inert atmosphere;
With
hydrogenchloride;
In
dichloromethane; water;
at 20 ℃;
for 2h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.3390/biom10101462
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 6 h / Reflux
2.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere
3.1: sodium ethanolate / toluene / 24 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
With
hydroxylamine hydrochloride; sodium ethanolate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; toluene;
3.1: |Neber Rearrangement / 3.2: |Neber Rearrangement;
DOI:10.3390/biom10101462
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / ethanol / 24 h / 20 °C
2.1: sodium acetate / ethanol / 3 h / Reflux
3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 6 h / Reflux
4.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.1: sodium ethanolate / toluene / 24 h / 20 °C / Inert atmosphere
5.2: 2 h / 20 °C / Inert atmosphere
With
hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; toluene;
1.1: |Claisen-Schmidt Condensation / 5.1: |Neber Rearrangement / 5.2: |Neber Rearrangement;
DOI:10.3390/biom10101462
