Acetamide, 2,2,2-trifluoro-N-[2-methyl-4-(2-methylpropyl)-5-oxazolyl]-N-(phenylmeth yl)-

Base Information

• Chemical Name: Acetamide, 2,2,2-trifluoro-N-[2-methyl-4-(2-methylpropyl)-5-oxazolyl]-N-(phenylmeth yl)-
• CAS No.: 87783-64-0
• Molecular Formula: C17H19F3N2O2
• Molecular Weight: 340.345
• Mol file: 87783-64-0.mol

Synonyms:

Chemical Property of Acetamide, 2,2,2-trifluoro-N-[2-methyl-4-(2-methylpropyl)-5-oxazolyl]-N-(phenylmeth yl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, 2,2,2-trifluoro-N-[2-methyl-4-(2-methylpropyl)-5-oxazolyl]-N-(phenylmeth yl)-

There total 3 articles about Acetamide, 2,2,2-trifluoro-N-[2-methyl-4-(2-methylpropyl)-5-oxazolyl]-N-(phenylmeth yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(acetylamino)-4-methyl-N-(phenylmethyl)pentanamide (87783-60-6) + trifluoroacetic anhydride (407-25-0) → 2-methyl-4-isobutyl-5-(N-benzyltrifluoroacetamido)oxazole (87783-64-0)

Guidance literature:

In dichloromethane; trifluoroacetic acid; for 18h; Ambient temperature;

DOI:10.1021/ja00364a041

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → 2-methyl-4-isobutyl-5-(N-benzyltrifluoroacetamido)oxazole (87783-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 °C

2: toluene / 0.5 h / 80 °C

3: 92 percent / trifluoroacetic acid; CH₂Cl₂ / 18 h / Ambient temperature

In dichloromethane; toluene; trifluoroacetic acid;

DOI:10.1021/ja00364a041

Reference yield:

(S)-4-isobutyl-2-methyloxazol-5(4H)-one (13649-95-1) → 2-methyl-4-isobutyl-5-(N-benzyltrifluoroacetamido)oxazole (87783-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 0.5 h / 80 °C

2: 92 percent / trifluoroacetic acid; CH₂Cl₂ / 18 h / Ambient temperature

In dichloromethane; toluene; trifluoroacetic acid;

DOI:10.1021/ja00364a041

upstream raw materials:

2-(acetylamino)-4-methyl-N-(phenylmethyl)pentanamide

trifluoroacetic anhydride

L-leucine

(S)-4-isobutyl-2-methyloxazol-5(4H)-one

Refernces