Furo[3,2-B]pyridin-2(3H)-one

Base Information

• Chemical Name: Furo[3,2-B]pyridin-2(3H)-one
• CAS No.: 88011-96-5
• Molecular Formula: C₇H₅NO₂
• Molecular Weight: 135.122
• DSSTox Substance ID: DTXSID80538992
• Nikkaji Number: J873.766E
• Wikidata: Q72479845
• Mol file: 88011-96-5.mol

Synonyms:FURO[3,2-B]PYRIDIN-2(3H)-ONE;88011-96-5;furopyridone;3H-FURO[3,2-B]PYRIDIN-2-ONE;SCHEMBL384843;DTXSID80538992;FNPYPLBPZILBRT-UHFFFAOYSA-N;AMY18960

Chemical Property of Furo[3,2-B]pyridin-2(3H)-one

Chemical Property:

• Melting Point: 145-146 °C
• Boiling Point: 269℃
• PKA: 2.73±0.20(Predicted)
• Flash Point: 116℃
• PSA: 39.19000
• Density: 1.360
• LogP: 0.54310
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 135.032028402
• Heavy Atom Count: 10
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

Furo[3,2-b]pyridin-2(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC=N2)OC1=O

Technology Process of Furo[3,2-B]pyridin-2(3H)-one

There total 3 articles about Furo[3,2-B]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.8%

3-acetoxypyridine-2-malononitrile (69539-63-5) → 2-oxo-2,3-dihydrofuro<3,2-b>pyridine (88011-96-5)

Guidance literature:

With PPA; at 100 ℃; for 4.5h;

Reference yield: 37.0%

3-hydroxy-2-pyridineacetic acid (69022-71-5) → 2-oxo-2,3-dihydrofuro<3,2-b>pyridine (88011-96-5)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; for 3h; Ambient temperature;

Reference yield:

2-aminofuro<3,2-b>pyridine-3-carboxamide (69539-69-1) → 2-oxo-2,3-dihydrofuro<3,2-b>pyridine (88011-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91.1 percent / H₂SO₄/H₂O (1:1) / 20 h / 130 °C

2: 37 percent / pyridine, tosyl chloride / 3 h / Ambient temperature

With pyridine; sulfuric acid; water; p-toluenesulfonyl chloride;

upstream raw materials:

3-acetoxypyridine-2-malononitrile

3-hydroxy-2-pyridineacetic acid

2-aminofuro<3,2-b>pyridine-3-carboxamide