1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene

Base Information

Chemical Name:1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene
CAS No.:88023-79-4
Molecular Formula:C9H8ClF3O
Molecular Weight:224.61
Hs Code.:
DSSTox Substance ID:DTXSID60521221
Wikidata:Q82385574

Synonyms:88023-79-4;1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene;1-((Chloromethoxy)methyl)-3-(trifluoromethyl)benzene;chloromethyl 3-trifluoromethylbenzyl ether;chloromethyl 3-trifluoromethyl-benzyl ether;SCHEMBL10815216;DTXSID60521221;MFCD25968328;SY309307

Suppliers and Price of 1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:224.0215771
Heavy Atom Count:14
Complexity:172

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)C(F)(F)F)COCCl

Technology Process of 1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene

There total 2 articles about 1-[(Chloromethoxy)methyl]-3-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 88023-85-2
methylthiomethyl 3-trifluoromethylbenzyl ether

: 88023-79-4
chloromethyl 3-trifluoromethylbenzyl ether

Guidance literature:: With sulfuryl dichloride; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1055/s-1983-30506

Reference yield:

: 349-75-7
3-(trifluoromethyl)benzyl alcohol

: 88023-79-4
chloromethyl 3-trifluoromethylbenzyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, NaI / 1.) liq. paraffin, 1,2-dimethoxyethane, 4 deg C, 30 min, 2.) liq. paraffin, 1,2-dimethoxyethane, RT, 6 h

2: 89 percent / SO₂Cl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

With sulfuryl dichloride; sodium hydride; sodium iodide; In dichloromethane;
DOI:10.1016/0223-5234(93)90014-6