Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]-

Base Information

Chemical Name:Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]-
CAS No.:88035-38-5
Molecular Formula:C₂₀H₂₂ClNO₂S
Molecular Weight:375.919
Hs Code.:
DSSTox Substance ID:DTXSID80361146
Mol file:88035-38-5.mol

Synonyms:Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]-;Oprea1_872668;88035-38-5;DTXSID80361146

Suppliers and Price of Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]-

Chemical Property:

PSA：45.76000
LogP:5.92530
XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:375.1059778
Heavy Atom Count:25
Complexity:547

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C(=CN2CCCCC2)C3=CC=C(C=C3)Cl

Technology Process of Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]-

There total 3 articles about Piperidine, 1-[2-(4-chlorophenyl)-2-[(4-methylphenyl)sulfonyl]ethenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 110-89-4
piperidine

: (4-Chloro-phenyl)-(toluene-4-sulfonyl)-acetaldehyde

: 88035-38-5
1-[(E)-2-(4-Chloro-phenyl)-2-(toluene-4-sulfonyl)-vinyl]-piperidine

Guidance literature:: In dichloromethane; for 4h; Ambient temperature;
DOI:10.1055/s-1983-30449

Reference yield:

: 7569-26-8
chloromethyl p-tolylsulfone

: 88035-38-5
1-[(E)-2-(4-Chloro-phenyl)-2-(toluene-4-sulfonyl)-vinyl]-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / 50percent aq. NaOH / benzyltriethylammonium chloride / acetonitrile / 1 h / Ambient temperature

2: boron trifluoride-etherate / CH₂Cl₂ / 0.17 h / 0 °C

3: 34 percent / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydroxide; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; acetonitrile;
DOI:10.1055/s-1983-30449

Reference yield:

: 88017-66-7,89333-01-7
trans epoxy-p-chlorostyryl p-tolylsulphone

: 88035-38-5
1-[(E)-2-(4-Chloro-phenyl)-2-(toluene-4-sulfonyl)-vinyl]-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride-etherate / CH₂Cl₂ / 0.17 h / 0 °C

2: 34 percent / CH₂Cl₂ / 4 h / Ambient temperature

With boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1055/s-1983-30449