2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione

Base Information

Chemical Name:2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione
CAS No.:88039-26-3
Molecular Formula:C16H13ClO2
Molecular Weight:272.731
Hs Code.:
DSSTox Substance ID:DTXSID20520033

Synonyms:2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione;88039-26-3;DTXSID20520033

Suppliers and Price of 2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:272.0604073
Heavy Atom Count:19
Complexity:326

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)C(C(=O)C2=CC=CC=C2)Cl

Technology Process of 2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione

There total 6 articles about 2-Chloro-1-(4-methylphenyl)-3-phenylpropane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 25855-99-6
1-(4-methylphenyl)-3-phenyl-1,3-propanedione

: 88039-26-3
2-chloro-1-phenyl-3-(p-tolyl)propane-1,3-dione

Guidance literature:: 1-(4-methylphenyl)-3-phenyl-1,3-propanedione; With chloro-trimethyl-silane; In acetonitrile; at 20 ℃; for 0.166667h;

With [bis(acetoxy)iodo]benzene; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1055/s-0035-1561572

Reference yield:

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 88039-26-3
2-chloro-1-phenyl-3-(p-tolyl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: chloro-trimethyl-silane / acetonitrile / 0.17 h / 20 °C

2.2: 2 h / 20 °C

With chloro-trimethyl-silane; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1055/s-0035-1561572

Reference yield:

: 122-00-9
para-methylacetophenone

: 88039-26-3
2-chloro-1-phenyl-3-(p-tolyl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: chloro-trimethyl-silane / acetonitrile / 0.17 h / 20 °C

2.2: 2 h / 20 °C

With chloro-trimethyl-silane; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1055/s-0035-1561572