Technology Process of 1H-Indole-1-carboxylic acid,
4-[1-hydroxy-2-[methyl(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl
ester
There total 6 articles about 1H-Indole-1-carboxylic acid,
4-[1-hydroxy-2-[methyl(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / H2 / 10percent Pd/C / methanol / 0.75 h / 3361.5 Torr
2: 2) dilute HCl / 1) THF-ether, reflux, 2 h, 2) steam bath, 5 min
3: 76 percent / potassium t-butoxide / tetrahydrofuran / 3 h / Heating
4: 77 percent / 2-pyrrolidinone hydrotribromide, pyrrolidinone / tetrahydrofuran / 3 h / Heating
5: tetrahydrofuran / 1 h / ice bath
6: NaBH4 / methanol
With
2-pyrrolidinon; hydrogenchloride; sodium tetrahydroborate; pyrrolidone hydrotribromide; potassium tert-butylate; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2) dilute HCl / 1) THF-ether, reflux, 2 h, 2) steam bath, 5 min
2: 76 percent / potassium t-butoxide / tetrahydrofuran / 3 h / Heating
3: 77 percent / 2-pyrrolidinone hydrotribromide, pyrrolidinone / tetrahydrofuran / 3 h / Heating
4: tetrahydrofuran / 1 h / ice bath
5: NaBH4 / methanol
With
2-pyrrolidinon; hydrogenchloride; sodium tetrahydroborate; pyrrolidone hydrotribromide; potassium tert-butylate;
In
tetrahydrofuran; methanol;
